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The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα- and Extracellular Signal-Regulated Kinase 1/2-Dependent Mechanism.
Guardiola-Serrano F, Beteta-Göbel R, Rodríguez-Lorca R, Ibarguren M, López DJ, Terés S, Alvarez R, Alonso-Sande M, Busquets X, Escribá PV. Guardiola-Serrano F, et al. Among authors: alonso sande m. J Pharmacol Exp Ther. 2015 Aug;354(2):213-24. doi: 10.1124/jpet.114.222281. Epub 2015 Jun 11. J Pharmacol Exp Ther. 2015. PMID: 26065701
The triacylglycerol, hydroxytriolein, inhibits triple negative mammary breast cancer cell proliferation through a mechanism dependent on dihydroceramide and Akt.
Guardiola-Serrano F, Beteta-Göbel R, Rodríguez-Lorca R, Ibarguren M, López DJ, Terés S, Alonso-Sande M, Higuera M, Torres M, Busquets X, Escribá PV. Guardiola-Serrano F, et al. Among authors: alonso sande m. Oncotarget. 2019 Apr 2;10(26):2486-2507. doi: 10.18632/oncotarget.26824. eCollection 2019 Apr 2. Oncotarget. 2019. PMID: 31069012 Free PMC article.
Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets.
Piotto S, Concilio S, Bianchino E, Iannelli P, López DJ, Terés S, Ibarguren M, Barceló-Coblijn G, Martin ML, Guardiola-Serrano F, Alonso-Sande M, Funari SS, Busquets X, Escribá PV. Piotto S, et al. Among authors: alonso sande m. Biochim Biophys Acta. 2014 Jun;1838(6):1628-37. doi: 10.1016/j.bbamem.2013.12.023. Epub 2014 Jan 9. Biochim Biophys Acta. 2014. PMID: 24412218 Free article.
Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells.
Martin ML, Liebisch G, Lehneis S, Schmitz G, Alonso-Sande M, Bestard-Escalas J, Lopez DH, García-Verdugo JM, Soriano-Navarro M, Busquets X, Escribá PV, Barceló-Coblijn G. Martin ML, et al. Among authors: alonso sande m. J Lipid Res. 2013 May;54(5):1457-65. doi: 10.1194/jlr.M036749. Epub 2013 Mar 7. J Lipid Res. 2013. PMID: 23471028 Free PMC article.
Development of PLGA-mannosamine nanoparticles as oral protein carriers.
Alonso-Sande M, des Rieux A, Fievez V, Sarmento B, Delgado A, Evora C, Remuñán-López C, Préat V, Alonso MJ. Alonso-Sande M, et al. Biomacromolecules. 2013 Nov 11;14(11):4046-52. doi: 10.1021/bm401141u. Epub 2013 Oct 30. Biomacromolecules. 2013. PMID: 24131254