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Protective role of RIPK1 scaffolding against HDV-induced hepatocyte cell death and the significance of cytokines in mice.
Camps G, Maestro S, Torella L, Herrero D, Usai C, Bilbao-Arribas M, Aldaz A, Olagüe C, Vales A, Suárez-Amarán L, Aldabe R, Gonzalez-Aseguinolaza G. Camps G, et al. Among authors: torella l. PLoS Pathog. 2024 May 13;20(5):e1011749. doi: 10.1371/journal.ppat.1011749. eCollection 2024 May. PLoS Pathog. 2024. PMID: 38739648 Free PMC article.
Efficient and safe therapeutic use of paired Cas9-nickases for primary hyperoxaluria type 1.
Torella L, Klermund J, Bilbao-Arribas M, Tamayo I, Andrieux G, Chmielewski KO, Vales A, Olagüe C, Moreno-Luqui D, Raimondi I, Abad A, Torrens-Baile J, Salido E, Huarte M, Hernaez M, Boerries M, Cathomen T, Zabaleta N, Gonzalez-Aseguinolaza G. Torella L, et al. EMBO Mol Med. 2024 Jan;16(1):112-131. doi: 10.1038/s44321-023-00008-8. Epub 2024 Jan 5. EMBO Mol Med. 2024. PMID: 38182795 Free PMC article.
Differential Trafficking and Expression of PIR Proteins in Acute and Chronic Plasmodium Infections.
Giorgalli M, Cunningham DA, Broncel M, Sait A, Harrison TE, Hosking C, Vandomme A, Amis SI, Antonello A, Sullivan L, Uwadiae F, Torella L, Higgins MK, Langhorne J. Giorgalli M, et al. Among authors: torella l. Front Cell Infect Microbiol. 2022 Jun 16;12:877253. doi: 10.3389/fcimb.2022.877253. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35782145 Free PMC article.
mRNA and gene editing: Late breaking therapies in liver diseases.
Zabaleta N, Torella L, Weber ND, Gonzalez-Aseguinolaza G. Zabaleta N, et al. Among authors: torella l. Hepatology. 2022 Sep;76(3):869-887. doi: 10.1002/hep.32441. Epub 2022 Apr 1. Hepatology. 2022. PMID: 35243655 Free PMC article. Review.
In Vitro and In Vivo Genetic Disease Modeling via NHEJ-Precise Deletions Using CRISPR-Cas9.
López-Manzaneda S, Ojeda-Pérez I, Zabaleta N, García-Torralba A, Alberquilla O, Torres R, Sánchez-Domínguez R, Torella L, Olivier E, Mountford J, Ramírez JC, Bueren JA, González-Aseguinolaza G, Segovia JC. López-Manzaneda S, et al. Among authors: torella l. Mol Ther Methods Clin Dev. 2020 Oct 15;19:426-437. doi: 10.1016/j.omtm.2020.10.007. eCollection 2020 Dec 11. Mol Ther Methods Clin Dev. 2020. PMID: 33294491 Free PMC article.
CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I.
Zabaleta N, Barberia M, Martin-Higueras C, Zapata-Linares N, Betancor I, Rodriguez S, Martinez-Turrillas R, Torella L, Vales A, Olagüe C, Vilas-Zornoza A, Castro-Labrador L, Lara-Astiaso D, Prosper F, Salido E, Gonzalez-Aseguinolaza G, Rodriguez-Madoz JR. Zabaleta N, et al. Among authors: torella l. Nat Commun. 2018 Dec 21;9(1):5454. doi: 10.1038/s41467-018-07827-1. Nat Commun. 2018. PMID: 30575740 Free PMC article.
Modelling non-Markovian dynamics in biochemical reactions.
Chiarugi D, Falaschi M, Hermith D, Olarte C, Torella L. Chiarugi D, et al. Among authors: torella l. BMC Syst Biol. 2015;9 Suppl 3(Suppl 3):S8. doi: 10.1186/1752-0509-9-S3-S8. Epub 2015 Jun 1. BMC Syst Biol. 2015. PMID: 26051249 Free PMC article.