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Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.
Gavai AV, Quesnelle C, Norris D, Han WC, Gill P, Shan W, Balog A, Chen K, Tebben A, Rampulla R, Wu DR, Zhang Y, Mathur A, White R, Rose A, Wang H, Yang Z, Ranasinghe A, D'Arienzo C, Guarino V, Xiao L, Su C, Everlof G, Arora V, Shen DR, Cvijic ME, Menard K, Wen ML, Meredith J, Trainor G, Lombardo LJ, Olson R, Baran PS, Hunt JT, Vite GD, Fischer BS, Westhouse RA, Lee FY. Gavai AV, et al. Among authors: chen k. ACS Med Chem Lett. 2015 Mar 11;6(5):523-7. doi: 10.1021/acsmedchemlett.5b00001. eCollection 2015 May 14. ACS Med Chem Lett. 2015. PMID: 26005526 Free PMC article.
Strain release in C-H bond activation?
Chen K, Eschenmoser A, Baran PS. Chen K, et al. Angew Chem Int Ed Engl. 2009;48(51):9705-8. doi: 10.1002/anie.200904474. Angew Chem Int Ed Engl. 2009. PMID: 19937877 Free PMC article.
Regioselective bromination of fused heterocyclic N-oxides.
Wengryniuk SE, Weickgenannt A, Reiher C, Strotman NA, Chen K, Eastgate MD, Baran PS. Wengryniuk SE, et al. Among authors: chen k. Org Lett. 2013 Feb 15;15(4):792-5. doi: 10.1021/ol3034675. Epub 2013 Jan 25. Org Lett. 2013. PMID: 23350852
Scalable and sustainable electrochemical allylic C-H oxidation.
Horn EJ, Rosen BR, Chen Y, Tang J, Chen K, Eastgate MD, Baran PS. Horn EJ, et al. Among authors: chen k, chen y. Nature. 2016 May 5;533(7601):77-81. doi: 10.1038/nature17431. Epub 2016 Apr 20. Nature. 2016. PMID: 27096371 Free PMC article.
A Scalable Total Synthesis of (-)-Nakadomarin A.
Boeckman RK Jr, Wang H, Rugg KW, Genung NE, Chen K, Ryder TR. Boeckman RK Jr, et al. Among authors: chen k. Org Lett. 2016 Dec 2;18(23):6136-6139. doi: 10.1021/acs.orglett.6b03137. Epub 2016 Nov 11. Org Lett. 2016. PMID: 27934385
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