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The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ Jr, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R. Herman JD, et al. Among authors: pepper lr. Sci Transl Med. 2015 May 20;7(288):288ra77. doi: 10.1126/scitranslmed.aaa3575. Sci Transl Med. 2015. PMID: 25995223 Free PMC article.
A decade of yeast surface display technology: where are we now?
Pepper LR, Cho YK, Boder ET, Shusta EV. Pepper LR, et al. Comb Chem High Throughput Screen. 2008 Feb;11(2):127-34. doi: 10.2174/138620708783744516. Comb Chem High Throughput Screen. 2008. PMID: 18336206 Free PMC article. Review.