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The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ Jr, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R. Herman JD, et al. Among authors: keller tl. Sci Transl Med. 2015 May 20;7(288):288ra77. doi: 10.1126/scitranslmed.aaa3575. Sci Transl Med. 2015. PMID: 25995223 Free PMC article.
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M. Keller TL, et al. Nat Chem Biol. 2012 Feb 12;8(3):311-7. doi: 10.1038/nchembio.790. Nat Chem Biol. 2012. PMID: 22327401 Free PMC article.
Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL. Kim Y, et al. Among authors: keller tl. Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):8900-8911. doi: 10.1073/pnas.1913788117. Epub 2020 Apr 6. Proc Natl Acad Sci U S A. 2020. PMID: 32253314 Free PMC article.
Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.
Oishi H, Martinu T, Sato M, Matsuda Y, Hirayama S, Juvet SC, Guan Z, Saito T, Cypel M, Hwang DM, Keller TL, Whitman MR, Liu M, Keshavjee S. Oishi H, et al. Among authors: keller tl. J Heart Lung Transplant. 2016 Apr;35(4):518-27. doi: 10.1016/j.healun.2015.12.003. Epub 2015 Dec 10. J Heart Lung Transplant. 2016. PMID: 26787621
A secreted tyrosine kinase acts in the extracellular environment.
Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE Jr, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. Bordoli MR, et al. Among authors: keller tl. Cell. 2014 Aug 28;158(5):1033-1044. doi: 10.1016/j.cell.2014.06.048. Cell. 2014. PMID: 25171405 Free PMC article.
Tyrosine phosphorylation in signal transduction.
Roberts TM, Kaplan D, Morgan W, Keller T, Mamon H, Piwnica-Worms H, Druker B, Cohen B, Schaffhausen B, Whitman M, et al. Roberts TM, et al. Cold Spring Harb Symp Quant Biol. 1988;53 Pt 1:161-71. doi: 10.1101/sqb.1988.053.01.022. Cold Spring Harb Symp Quant Biol. 1988. PMID: 2855480 No abstract available.
19 results