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A eudesmane-type sesquiterpene isolated from Pluchea odorata (L.) Cass. combats three hallmarks of cancer cells: Unrestricted proliferation, escape from apoptosis and early metastatic outgrowth in vitro.
Blaschke M, McKinnon R, Nguyen CH, Holzner S, Zehl M, Atanasov AG, Schelch K, Krieger S, Diaz R, Frisch R, Feistel B, Jäger W, Ecker GF, Dirsch VM, Grusch M, Zupko I, Urban E, Kopp B, Krupitza G. Blaschke M, et al. Among authors: grusch m. Mutat Res. 2015 Jul;777:79-90. doi: 10.1016/j.mrfmmm.2015.04.011. Epub 2015 May 5. Mutat Res. 2015. PMID: 25989051
The MYC dualism in growth and death.
Fuhrmann G, Rosenberger G, Grusch M, Klein N, Hofmann J, Krupitza G. Fuhrmann G, et al. Among authors: grusch m. Mutat Res. 1999 Nov;437(3):205-17. doi: 10.1016/s1383-5742(99)00084-8. Mutat Res. 1999. PMID: 10592328 Review.
Cdc25A phosphatase suppresses apoptosis induced by serum deprivation.
Fuhrmann G, Leisser C, Rosenberger G, Grusch M, Huettenbrenner S, Halama T, Mosberger I, Sasgary S, Cerni C, Krupitza G. Fuhrmann G, et al. Among authors: grusch m. Oncogene. 2001 Jul 27;20(33):4542-53. doi: 10.1038/sj.onc.1204499. Oncogene. 2001. PMID: 11494150
Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside.
Grusch M, Polgar D, Gfatter S, Leuhuber K, Huettenbrenner S, Leisser C, Fuhrmann G, Kassie F, Steinkellner H, Smid K, Peters GJ, Jayaram HN, Klepal W, Szekeres T, Knasmüller S, Krupitza G. Grusch M, et al. Cell Death Differ. 2002 Feb;9(2):169-78. doi: 10.1038/sj.cdd.4400937. Cell Death Differ. 2002. PMID: 11840167
177 results