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Page 1
A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein.
White KM, De Jesus P, Chen Z, Abreu P Jr, Barile E, Mak PA, Anderson P, Nguyen QT, Inoue A, Stertz S, Koenig R, Pellecchia M, Palese P, Kuhen K, García-Sastre A, Chanda SK, Shaw ML. White KM, et al. Among authors: kuhen k. ACS Infect Dis. 2015 Feb 13;1(2):98-109. doi: 10.1021/id500022h. Epub 2014 Dec 15. ACS Infect Dis. 2015. PMID: 25984567 Free PMC article.
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.
König R, Zhou Y, Elleder D, Diamond TL, Bonamy GM, Irelan JT, Chiang CY, Tu BP, De Jesus PD, Lilley CE, Seidel S, Opaluch AM, Caldwell JS, Weitzman MD, Kuhen KL, Bandyopadhyay S, Ideker T, Orth AP, Miraglia LJ, Bushman FD, Young JA, Chanda SK. König R, et al. Among authors: kuhen kl. Cell. 2008 Oct 3;135(1):49-60. doi: 10.1016/j.cell.2008.07.032. Cell. 2008. PMID: 18854154 Free PMC article.
A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis.
Mak PA, Rao SP, Ping Tan M, Lin X, Chyba J, Tay J, Ng SH, Tan BH, Cherian J, Duraiswamy J, Bifani P, Lim V, Lee BH, Ling Ma N, Beer D, Thayalan P, Kuhen K, Chatterjee A, Supek F, Glynne R, Zheng J, Boshoff HI, Barry CE 3rd, Dick T, Pethe K, Camacho LR. Mak PA, et al. Among authors: kuhen k. ACS Chem Biol. 2012 Jul 20;7(7):1190-7. doi: 10.1021/cb2004884. Epub 2012 Apr 25. ACS Chem Biol. 2012. PMID: 22500615 Free PMC article.
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, Trager R, Caldwell JS, Schultz PG, Zhou Y, Winzeler EA. Plouffe D, et al. Among authors: kuhen k. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9059-64. doi: 10.1073/pnas.0802982105. Epub 2008 Jun 25. Proc Natl Acad Sci U S A. 2008. PMID: 18579783 Free PMC article.
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.
Pethe K, Sequeira PC, Agarwalla S, Rhee K, Kuhen K, Phong WY, Patel V, Beer D, Walker JR, Duraiswamy J, Jiricek J, Keller TH, Chatterjee A, Tan MP, Ujjini M, Rao SP, Camacho L, Bifani P, Mak PA, Ma I, Barnes SW, Chen Z, Plouffe D, Thayalan P, Ng SH, Au M, Lee BH, Tan BH, Ravindran S, Nanjundappa M, Lin X, Goh A, Lakshminarayana SB, Shoen C, Cynamon M, Kreiswirth B, Dartois V, Peters EC, Glynne R, Brenner S, Dick T. Pethe K, et al. Among authors: kuhen k. Nat Commun. 2010 Aug 24;1(5):57. doi: 10.1038/ncomms1060. Nat Commun. 2010. PMID: 20975714 Free PMC article.
Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling.
McAllister CS, Ansaldi D, Growcott EJ, Zhong Y, Quackenbush D, Wolff KC, Chen Z, Tanaseichuk O, Lelais G, Barnes SW, Federe GC, Luna F, Walker JR, Zhou Y, Kuhen KL. McAllister CS, et al. Among authors: kuhen kl. Virology. 2020 Jan 15;540:195-206. doi: 10.1016/j.virol.2019.10.007. Epub 2019 Oct 23. Virology. 2020. PMID: 31929001 Free article.
Cell-based optimization of novel benzamides as potential antimalarial leads.
Wu T, Nagle A, Sakata T, Henson K, Borboa R, Chen Z, Kuhen K, Plouffe D, Winzeler E, Adrian F, Tuntland T, Chang J, Simerson S, Howard S, Ek J, Isbell J, Deng X, Gray NS, Tully DC, Chatterjee AK. Wu T, et al. Among authors: kuhen k. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6970-4. doi: 10.1016/j.bmcl.2009.10.050. Epub 2009 Oct 29. Bioorg Med Chem Lett. 2009. PMID: 19879133 Free PMC article.
Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials.
Flannery EL, McNamara CW, Kim SW, Kato TS, Li F, Teng CH, Gagaring K, Manary MJ, Barboa R, Meister S, Kuhen K, Vinetz JM, Chatterjee AK, Winzeler EA. Flannery EL, et al. Among authors: kuhen k. ACS Chem Biol. 2015 Feb 20;10(2):413-20. doi: 10.1021/cb500616x. Epub 2014 Nov 5. ACS Chem Biol. 2015. PMID: 25322084 Free PMC article.
Imidazolopiperazines: lead optimization of the second-generation antimalarial agents.
Nagle A, Wu T, Kuhen K, Gagaring K, Borboa R, Francek C, Chen Z, Plouffe D, Lin X, Caldwell C, Ek J, Skolnik S, Liu F, Wang J, Chang J, Li C, Liu B, Hollenbeck T, Tuntland T, Isbell J, Chuan T, Alper PB, Fischli C, Brun R, Lakshminarayana SB, Rottmann M, Diagana TT, Winzeler EA, Glynne R, Tully DC, Chatterjee AK. Nagle A, et al. Among authors: kuhen k. J Med Chem. 2012 May 10;55(9):4244-73. doi: 10.1021/jm300041e. Epub 2012 Apr 23. J Med Chem. 2012. PMID: 22524250 Free PMC article.
Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents.
Yokokawa F, Wang G, Chan WL, Ang SH, Wong J, Ma I, Rao SP, Manjunatha U, Lakshminarayana SB, Herve M, Kounde C, Tan BH, Thayalan P, Ng SH, Nanjundappa M, Ravindran S, Gee P, Tan M, Wei L, Goh A, Chen PY, Lee KS, Zhong C, Wagner T, Dix I, Chatterjee AK, Pethe K, Kuhen K, Glynne R, Smith P, Bifani P, Jiricek J. Yokokawa F, et al. Among authors: kuhen k. ACS Med Chem Lett. 2013 Apr 1;4(5):451-5. doi: 10.1021/ml400071a. eCollection 2013 May 9. ACS Med Chem Lett. 2013. PMID: 24900693 Free PMC article.
52 results