Roth BL - Search Results

1

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.

Vardy E, Robinson JE, Li C, Olsen RHJ, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL. Vardy E, et al. Among authors: roth bl. Neuron. 2015 May 20;86(4):936-946. doi: 10.1016/j.neuron.2015.03.065. Epub 2015 Apr 30. Neuron. 2015. PMID: 25937170 Free PMC article.

2

Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors.

Yan F, Mosier PD, Westkaemper RB, Stewart J, Zjawiony JK, Vortherms TA, Sheffler DJ, Roth BL. Yan F, et al. Among authors: roth bl. Biochemistry. 2005 Jun 21;44(24):8643-51. doi: 10.1021/bi050490d. Biochemistry. 2005. PMID: 15952771

3

Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor.

Vortherms TA, Mosier PD, Westkaemper RB, Roth BL. Vortherms TA, et al. Among authors: roth bl. J Biol Chem. 2007 Feb 2;282(5):3146-56. doi: 10.1074/jbc.M609264200. Epub 2006 Nov 22. J Biol Chem. 2007. PMID: 17121830 Free article.

4

Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.

Dukat M, Mosier PD, Kolanos R, Roth BL, Glennon RA. Dukat M, et al. Among authors: roth bl. J Med Chem. 2008 Feb 14;51(3):603-11. doi: 10.1021/jm070910s. Epub 2008 Jan 18. J Med Chem. 2008. PMID: 18201064 Free PMC article.

5

Galpha-subunits differentially alter the conformation and agonist affinity of kappa-opioid receptors.

Yan F, Mosier PD, Westkaemper RB, Roth BL. Yan F, et al. Among authors: roth bl. Biochemistry. 2008 Feb 12;47(6):1567-78. doi: 10.1021/bi701476b. Epub 2008 Jan 19. Biochemistry. 2008. PMID: 18205395

6

Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor.

Dewkar GK, Peddi S, Mosier PD, Roth BL, Westkaemper RB. Dewkar GK, et al. Among authors: roth bl. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5268-71. doi: 10.1016/j.bmcl.2008.08.059. Epub 2008 Aug 22. Bioorg Med Chem Lett. 2008. PMID: 18774714 Free PMC article.

7

Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.

Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB. Runyon SP, et al. Among authors: roth bl. J Med Chem. 2008 Nov 13;51(21):6808-28. doi: 10.1021/jm800771x. Epub 2008 Oct 11. J Med Chem. 2008. PMID: 18847250 Free PMC article.

8

Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.

Tang H, Wang XS, Huang XP, Roth BL, Butler KV, Kozikowski AP, Jung M, Tropsha A. Tang H, et al. Among authors: roth bl. J Chem Inf Model. 2009 Feb;49(2):461-76. doi: 10.1021/ci800366f. J Chem Inf Model. 2009. PMID: 19182860

9

Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).

Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP. Kimple AJ, et al. Among authors: roth bl. J Biol Chem. 2009 Jul 17;284(29):19402-11. doi: 10.1074/jbc.M109.024711. Epub 2009 May 28. J Biol Chem. 2009. PMID: 19478087 Free PMC article.

10

Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor.

Yan F, Bikbulatov RV, Mocanu V, Dicheva N, Parker CE, Wetsel WC, Mosier PD, Westkaemper RB, Allen JA, Zjawiony JK, Roth BL. Yan F, et al. Among authors: roth bl. Biochemistry. 2009 Jul 28;48(29):6898-908. doi: 10.1021/bi900605n. Biochemistry. 2009. PMID: 19555087 Free PMC article.

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