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Esters of the marine-derived triterpene sipholenol A reverse P-GP-mediated drug resistance.
Mar Drugs. 2015 Apr 14;13(4):2267-86. doi: 10.3390/md13042267.
Mar Drugs. 2015.
PMID: 25874923
Free PMC article.
Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction.
Vispute SG, Bu P, Le Y, Cheng X.
Vispute SG, et al.
Toxicology. 2017 Mar 1;378:95-106. doi: 10.1016/j.tox.2017.01.009. Epub 2017 Jan 11.
Toxicology. 2017.
PMID: 28088388
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Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR).
Cheng X, Vispute SG, Liu J, Cheng C, Kharitonenkov A, Klaassen CD.
Cheng X, et al. Among authors: vispute sg.
Toxicol Appl Pharmacol. 2014 Jul 1;278(1):65-71. doi: 10.1016/j.taap.2014.04.013. Epub 2014 Apr 24.
Toxicol Appl Pharmacol. 2014.
PMID: 24769090
Free PMC article.
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Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™.
Sathish JG, Bhatt S, DaSilva JK, Flynn D, Jenkinson S, Kalgutkar AS, Liu M, Manickam B, Pinkstaff J, Reagan WJ, Shirai N, Shoieb AM, Sirivelu M, Vispute S, Vitsky A, Walters K, Wisialowski TA, Updyke LW.
Sathish JG, et al.
Int J Toxicol. 2022 Aug;41(4):276-290. doi: 10.1177/10915818221095489. Epub 2022 May 21.
Int J Toxicol. 2022.
PMID: 35603517
Free PMC article.
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Experiments in the EpiDerm 3D Skin In Vitro Model and Minipigs In Vivo Indicate Comparatively Lower In Vivo Skin Sensitivity of Topically Applied Aneugenic Compounds.
Schuler M, Tomlinson L, Homiski M, Cheung J, Zhan Y, Coffing S, Engel M, Rubitski E, Seitis G, Hales K, Robertson A, Vispute S, Cook J, Radi Z, Hollingshead B.
Schuler M, et al.
Toxicol Sci. 2021 Feb 26;180(1):103-121. doi: 10.1093/toxsci/kfaa189.
Toxicol Sci. 2021.
PMID: 33481035
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An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis.
Hollingshead BD, Tomlinson L, Finley J, Doshna C, Ritenour C, Barricklow J, Oppenheimer SR, O'Neil SP, Moore JL, Patterson NH, Nicholson SP, Norris JL, Caprioli RM, Beaumont K, King-Ahmad AJ, Vispute S, Cook JC, Radi Z, Schuler M.
Hollingshead BD, et al.
Regul Toxicol Pharmacol. 2021 Jul;123:104934. doi: 10.1016/j.yrtph.2021.104934. Epub 2021 Apr 16.
Regul Toxicol Pharmacol. 2021.
PMID: 33872740
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PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter.
Chen JJ, Sun YL, Tiwari AK, Xiao ZJ, Sodani K, Yang DH, Vispute SG, Jiang WQ, Chen SD, Chen ZS.
Chen JJ, et al. Among authors: vispute sg.
Cancer Sci. 2012 Aug;103(8):1531-7. doi: 10.1111/j.1349-7006.2012.02328.x. Epub 2012 Jul 6.
Cancer Sci. 2012.
PMID: 22578167
Free PMC article.
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