Varani K - Search Results

1

Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation.

Varano F, Catarzi D, Squarcialupi L, Betti M, Vincenzi F, Ravani A, Varani K, Dal Ben D, Thomas A, Volpini R, Colotta V. Varano F, et al. Among authors: varani k. Eur J Med Chem. 2015;96:105-21. doi: 10.1016/j.ejmech.2015.04.010. Epub 2015 Apr 4. Eur J Med Chem. 2015. PMID: 25874336

2

De novo analysis of receptor binding affinity data of 8-ethenyl-xanthine antagonists to adenosine A1 and A2a receptors.

Dalpiaz A, Gessi S, Varani K, Borea PA. Dalpiaz A, et al. Among authors: varani k. Arzneimittelforschung. 1997 May;47(5):591-4. Arzneimittelforschung. 1997. PMID: 9205770

3

Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.

Baraldi PG, Cacciari B, Spalluto G, Bergonzoni M, Dionisotti S, Ongini E, Varani K, Borea PA. Baraldi PG, et al. Among authors: varani k. J Med Chem. 1998 Jun 4;41(12):2126-33. doi: 10.1021/jm9708689. J Med Chem. 1998. PMID: 9622554

4

Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors.

Varani K, Cacciari B, Baraldi PG, Dionisotti S, Ongini E, Borea PA. Varani K, et al. Life Sci. 1998;63(5):PL 81-7. doi: 10.1016/s0024-3205(98)00289-6. Life Sci. 1998. PMID: 9714428

5

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.

Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Klotz KN, Leung E, Varani K, Gessi S, Merighi S, Borea PA. Baraldi PG, et al. Among authors: varani k. J Med Chem. 1999 Nov 4;42(22):4473-8. doi: 10.1021/jm991114s. J Med Chem. 1999. PMID: 10579811 No abstract available.

6

Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors.

Baraldi PG, Cacciari B, Romagnoli R, Varani K, Merighi S, Gessi S, Borea PA, Leung E, Hickey SL, Spalluto G. Baraldi PG, et al. Among authors: varani k. Bioorg Med Chem Lett. 2000 Feb 7;10(3):209-11. doi: 10.1016/s0960-894x(99)00674-5. Bioorg Med Chem Lett. 2000. PMID: 10698437

7

A(3) adenosine receptor ligands: history and perspectives.

Baraldi PG, Cacciari B, Romagnoli R, Merighi S, Varani K, Borea PA, Spalluto G. Baraldi PG, et al. Among authors: varani k. Med Res Rev. 2000 Mar;20(2):103-28. doi: 10.1002/(sici)1098-1128(200003)20:2<103::aid-med1>3.0.co;2-x. Med Res Rev. 2000. PMID: 10723024 Review.

8

[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.

Varani K, Merighi S, Gessi S, Klotz KN, Leung E, Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Borea PA. Varani K, et al. Mol Pharmacol. 2000 May;57(5):968-75. Mol Pharmacol. 2000. PMID: 10779381

9

Further studies on nociceptin-related peptides: discovery of a new chemical template with antagonist activity on the nociceptin receptor.

Guerrini R, Caló G, Bigoni R, Rizzi A, Varani K, Toth G, Gessi S, Hashiba E, Hashimoto Y, Lambert DG, Borea PA, Tomatis R, Salvadori S, Regoli D. Guerrini R, et al. Among authors: varani k. J Med Chem. 2000 Jul 27;43(15):2805-13. doi: 10.1021/jm990075h. J Med Chem. 2000. PMID: 10956188

10

Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen.

Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Moro S, Klotz KN, Leung E, Varani K, Gessi S, Merighi S, Borea PA. Baraldi PG, et al. Among authors: varani k. J Med Chem. 2000 Dec 14;43(25):4768-80. doi: 10.1021/jm001047y. J Med Chem. 2000. PMID: 11123985

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