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Scientific Review of the Proarrhythmic Risks of Oligonucleotide Therapeutics: Are Dedicated ICH S7B/E14 Studies Needed for Low-Risk Modalities?
Clin Pharmacol Ther. 2024 Feb 16. doi: 10.1002/cpt.3204. Online ahead of print.
Clin Pharmacol Ther. 2024.
PMID: 38362953
Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse.
Siddens LK, Bunde KL, Harper TA Jr, McQuistan TJ, Löhr CV, Bramer LM, Waters KM, Tilton SC, Krueger SK, Williams DE, Baird WM.
Siddens LK, et al. Among authors: harper ta jr.
Toxicol Appl Pharmacol. 2015 Sep 1;287(2):149-160. doi: 10.1016/j.taap.2015.05.019. Epub 2015 Jun 3.
Toxicol Appl Pharmacol. 2015.
PMID: 26049101
Free PMC article.
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Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS.
Harper TA Jr, Morré J, Lauer FT, McQuistan TJ, Hummel JM, Burchiel SW, Williams DE.
Harper TA Jr, et al.
Mutat Res Genet Toxicol Environ Mutagen. 2015 Apr;782:51-6. doi: 10.1016/j.mrgentox.2015.03.007. Epub 2015 Mar 12.
Mutat Res Genet Toxicol Environ Mutagen. 2015.
PMID: 25868132
Free PMC article.
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Aryl hydrocarbon receptor-dependent stanniocalcin 2 induction by cinnabarinic acid provides cytoprotection against endoplasmic reticulum and oxidative stress.
Joshi AD, Carter DE, Harper TA Jr, Elferink CJ.
Joshi AD, et al. Among authors: harper ta jr.
J Pharmacol Exp Ther. 2015 Apr;353(1):201-12. doi: 10.1124/jpet.114.222265. Epub 2015 Feb 11.
J Pharmacol Exp Ther. 2015.
PMID: 25672339
Free PMC article.
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Identification of stanniocalcin 2 as a novel aryl hydrocarbon receptor target gene.
Harper TA Jr, Joshi AD, Elferink CJ.
Harper TA Jr, et al.
J Pharmacol Exp Ther. 2013 Mar;344(3):579-88. doi: 10.1124/jpet.112.201111. Epub 2012 Dec 26.
J Pharmacol Exp Ther. 2013.
PMID: 23269473
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