Chimenti MS - Search Results

1

Biophysical methods for identifying fragment-based inhibitors of protein-protein interactions.

Pfaff SJ, Chimenti MS, Kelly MJ, Arkin MR. Pfaff SJ, et al. Among authors: chimenti ms. Methods Mol Biol. 2015;1278:587-613. doi: 10.1007/978-1-4939-2425-7_39. Methods Mol Biol. 2015. PMID: 25859978

2

A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP.

Chimenti MS, Bulfer SL, Neitz RJ, Renslo AR, Jacobson MP, James TL, Arkin MR, Kelly MJ. Chimenti MS, et al. J Biomol Screen. 2015 Jul;20(6):788-800. doi: 10.1177/1087057115570550. Epub 2015 Feb 17. J Biomol Screen. 2015. PMID: 25690569

3

Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.

Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, Arkin MR, Wipf P, Huryn DM. Alverez C, et al. Among authors: chimenti ms. ACS Med Chem Lett. 2015 Dec 22;7(2):182-7. doi: 10.1021/acsmedchemlett.5b00396. eCollection 2016 Feb 11. ACS Med Chem Lett. 2015. PMID: 26985295 Free PMC article.

4

pH sensing by FAK-His58 regulates focal adhesion remodeling.

Choi CH, Webb BA, Chimenti MS, Jacobson MP, Barber DL. Choi CH, et al. Among authors: chimenti ms. J Cell Biol. 2013 Sep 16;202(6):849-59. doi: 10.1083/jcb.201302131. J Cell Biol. 2013. PMID: 24043700 Free PMC article.

5

Structural origins of high apparent dielectric constants experienced by ionizable groups in the hydrophobic core of a protein.

Chimenti MS, Castañeda CA, Majumdar A, García-Moreno E B. Chimenti MS, et al. J Mol Biol. 2011 Jan 14;405(2):361-77. doi: 10.1016/j.jmb.2010.10.001. Epub 2010 Nov 6. J Mol Biol. 2011. PMID: 21059359 Free PMC article.

6

Electrostatic effects in a network of polar and ionizable groups in staphylococcal nuclease.

Baran KL, Chimenti MS, Schlessman JL, Fitch CA, Herbst KJ, Garcia-Moreno BE. Baran KL, et al. Among authors: chimenti ms. J Mol Biol. 2008 Jun 20;379(5):1045-62. doi: 10.1016/j.jmb.2008.04.021. Epub 2008 Apr 16. J Mol Biol. 2008. PMID: 18499123

7

Dysregulated pH: a perfect storm for cancer progression.

Webb BA, Chimenti M, Jacobson MP, Barber DL. Webb BA, et al. Nat Rev Cancer. 2011 Aug 11;11(9):671-7. doi: 10.1038/nrc3110. Nat Rev Cancer. 2011. PMID: 21833026 Review.

8

Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).

Kumar P, Chimenti MS, Pemble H, Schönichen A, Thompson O, Jacobson MP, Wittmann T. Kumar P, et al. Among authors: chimenti ms. J Biol Chem. 2012 May 18;287(21):17050-17064. doi: 10.1074/jbc.M111.316661. Epub 2012 Mar 29. J Biol Chem. 2012. PMID: 22467876 Free PMC article.

9

A buried lysine that titrates with a normal pKa: role of conformational flexibility at the protein-water interface as a determinant of pKa values.

Harms MJ, Schlessman JL, Chimenti MS, Sue GR, Damjanović A, García-Moreno B. Harms MJ, et al. Among authors: chimenti ms. Protein Sci. 2008 May;17(5):833-45. doi: 10.1110/ps.073397708. Epub 2008 Mar 27. Protein Sci. 2008. PMID: 18369193 Free PMC article.

10

Structural reorganization triggered by charging of Lys residues in the hydrophobic interior of a protein.

Chimenti MS, Khangulov VS, Robinson AC, Heroux A, Majumdar A, Schlessman JL, García-Moreno B. Chimenti MS, et al. Structure. 2012 Jun 6;20(6):1071-85. doi: 10.1016/j.str.2012.03.023. Epub 2012 May 25. Structure. 2012. PMID: 22632835 Free PMC article.

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