Chen W - Search Results

1

Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.

Ren XR, Wang J, Osada T, Mook RA Jr, Morse MA, Barak LS, Lyerly HK, Chen W. Ren XR, et al. Among authors: chen w. Breast Cancer Res. 2015 Feb 15;17(1):20. doi: 10.1186/s13058-015-0528-9. Breast Cancer Res. 2015. PMID: 25849870 Free PMC article.

2

Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.

Ren XR, Wei J, Lei G, Wang J, Lu J, Xia W, Spector N, Barak LS, Clay TM, Osada T, Hamilton E, Blackwell K, Hobeika AC, Morse MA, Lyerly HK, Chen W. Ren XR, et al. Among authors: chen w. Breast Cancer Res. 2012 Jun 7;14(3):R89. doi: 10.1186/bcr3204. Breast Cancer Res. 2012. PMID: 22676470 Free PMC article.

3

Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers.

Osada T, Hartman ZC, Wei J, Lei G, Hobeika AC, Gwin WR, Diniz MA, Spector N, Clay TM, Chen W, Morse MA, Lyerly HK. Osada T, et al. Among authors: chen w. Breast Cancer Res. 2018 Aug 9;20(1):90. doi: 10.1186/s13058-018-1023-x. Breast Cancer Res. 2018. PMID: 30092835 Free PMC article.

4

Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo.

Morse MA, Wei J, Hartman Z, Xia W, Ren XR, Lei G, Barry WT, Osada T, Hobeika AC, Peplinski S, Jiang H, Devi GR, Chen W, Spector N, Amalfitano A, Lyerly HK, Clay TM. Morse MA, et al. Among authors: chen w. Int J Cancer. 2010 Jun 15;126(12):2893-903. doi: 10.1002/ijc.24995. Int J Cancer. 2010. PMID: 19856307 Free PMC article.

5

Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.

Osada T, Chen M, Yang XY, Spasojevic I, Vandeusen JB, Hsu D, Clary BM, Clay TM, Chen W, Morse MA, Lyerly HK. Osada T, et al. Among authors: chen m, chen w. Cancer Res. 2011 Jun 15;71(12):4172-82. doi: 10.1158/0008-5472.CAN-10-3978. Epub 2011 Apr 29. Cancer Res. 2011. PMID: 21531761 Free PMC article.

6

Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis.

Mook RA Jr, Ren XR, Wang J, Piao H, Barak LS, Kim Lyerly H, Chen W. Mook RA Jr, et al. Among authors: chen w. Bioorg Med Chem. 2017 Mar 15;25(6):1804-1816. doi: 10.1016/j.bmc.2017.01.046. Epub 2017 Feb 3. Bioorg Med Chem. 2017. PMID: 28233680 Free PMC article.

7

Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.

Bhattacharyya J, Ren XR, Mook RA, Wang J, Spasojevic I, Premont RT, Li X, Chilkoti A, Chen W. Bhattacharyya J, et al. Among authors: chen w. Nanoscale. 2017 Aug 31;9(34):12709-12717. doi: 10.1039/c7nr01973d. Nanoscale. 2017. PMID: 28828438 Free PMC article.

8

Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.

Mook RA Jr, Wang J, Ren XR, Chen M, Spasojevic I, Barak LS, Lyerly HK, Chen W. Mook RA Jr, et al. Among authors: chen m, chen w. Bioorg Med Chem. 2015 Sep 1;23(17):5829-38. doi: 10.1016/j.bmc.2015.07.001. Epub 2015 Aug 10. Bioorg Med Chem. 2015. PMID: 26272032 Free PMC article.

9

Niclosamide: Beyond an antihelminthic drug.

Chen W, Mook RA Jr, Premont RT, Wang J. Chen W, et al. Cell Signal. 2018 Jan;41:89-96. doi: 10.1016/j.cellsig.2017.04.001. Epub 2017 Apr 4. Cell Signal. 2018. PMID: 28389414 Free PMC article. Review.

10

Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth.

Wang J, Mook RA Jr, Ren XR, Zhang Q, Jing G, Lu M, Spasojevic I, Lyerly HK, Hsu D, Chen W. Wang J, et al. Among authors: chen w. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442. doi: 10.1016/j.bmc.2018.09.016. Epub 2018 Sep 17. Bioorg Med Chem. 2018. PMID: 30274939 Free PMC article.

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