Barak LS - Search Results

1

Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.

Ren XR, Wang J, Osada T, Mook RA Jr, Morse MA, Barak LS, Lyerly HK, Chen W. Ren XR, et al. Among authors: barak ls. Breast Cancer Res. 2015 Feb 15;17(1):20. doi: 10.1186/s13058-015-0528-9. Breast Cancer Res. 2015. PMID: 25849870 Free PMC article.

2

Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.

Ren XR, Wei J, Lei G, Wang J, Lu J, Xia W, Spector N, Barak LS, Clay TM, Osada T, Hamilton E, Blackwell K, Hobeika AC, Morse MA, Lyerly HK, Chen W. Ren XR, et al. Among authors: barak ls. Breast Cancer Res. 2012 Jun 7;14(3):R89. doi: 10.1186/bcr3204. Breast Cancer Res. 2012. PMID: 22676470 Free PMC article.

3

Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis.

Mook RA Jr, Ren XR, Wang J, Piao H, Barak LS, Kim Lyerly H, Chen W. Mook RA Jr, et al. Among authors: barak ls. Bioorg Med Chem. 2017 Mar 15;25(6):1804-1816. doi: 10.1016/j.bmc.2017.01.046. Epub 2017 Feb 3. Bioorg Med Chem. 2017. PMID: 28233680 Free PMC article.

4

Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.

Mook RA Jr, Wang J, Ren XR, Chen M, Spasojevic I, Barak LS, Lyerly HK, Chen W. Mook RA Jr, et al. Among authors: barak ls. Bioorg Med Chem. 2015 Sep 1;23(17):5829-38. doi: 10.1016/j.bmc.2015.07.001. Epub 2015 Aug 10. Bioorg Med Chem. 2015. PMID: 26272032 Free PMC article.

5

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

Chen M, Wang J, Lu J, Bond MC, Ren XR, Lyerly HK, Barak LS, Chen W. Chen M, et al. Among authors: barak ls. Biochemistry. 2009 Nov 3;48(43):10267-74. doi: 10.1021/bi9009677. Biochemistry. 2009. PMID: 19772353 Free PMC article.

6

Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine.

Wang J, Lu J, Bond MC, Chen M, Ren XR, Lyerly HK, Barak LS, Chen W. Wang J, et al. Among authors: barak ls. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9323-8. doi: 10.1073/pnas.0910712107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439738 Free PMC article.

7

The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks.

Wang J, Lu J, Mook RA Jr, Zhang M, Zhao S, Barak LS, Freedman JH, Lyerly HK, Chen W. Wang J, et al. Among authors: barak ls. Toxicol Sci. 2012 Aug;128(2):517-23. doi: 10.1093/toxsci/kfs165. Epub 2012 May 1. Toxicol Sci. 2012. PMID: 22552772 Free PMC article.

8

Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.

Wang J, Mook RA Jr, Lu J, Gooden DM, Ribeiro A, Guo A, Barak LS, Lyerly HK, Chen W. Wang J, et al. Among authors: barak ls. Bioorg Med Chem. 2012 Nov 15;20(22):6751-7. doi: 10.1016/j.bmc.2012.09.030. Epub 2012 Sep 23. Bioorg Med Chem. 2012. PMID: 23063522 Free PMC article.

9

Small molecule modulators of Wnt/β-catenin signaling.

Mook RA Jr, Chen M, Lu J, Barak LS, Lyerly HK, Chen W. Mook RA Jr, et al. Among authors: barak ls. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2187-91. doi: 10.1016/j.bmcl.2013.01.101. Epub 2013 Jan 30. Bioorg Med Chem Lett. 2013. PMID: 23453073 Free PMC article.

10

Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1.

Lu J, Chen M, Ren XR, Wang J, Lyerly HK, Barak L, Chen W. Lu J, et al. PLoS One. 2013 May 3;8(5):e63353. doi: 10.1371/journal.pone.0063353. Print 2013. PLoS One. 2013. PMID: 23671675 Free PMC article.

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