Downey SL - Search Results

1

Downey SL, Florea BI, Overkleeft HS, Kisselev AF. Downey SL, et al. Curr Protoc Immunol. 2015 Apr 1;109:9.10.1-9.10.8. doi: 10.1002/0471142735.im0910s109. Curr Protoc Immunol. 2015. PMID: 25845565

2

Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.

Britton M, Lucas MM, Downey SL, Screen M, Pletnev AA, Verdoes M, Tokhunts RA, Amir O, Goddard AL, Pelphrey PM, Wright DL, Overkleeft HS, Kisselev AF. Britton M, et al. Among authors: downey sl. Chem Biol. 2009 Dec 24;16(12):1278-89. doi: 10.1016/j.chembiol.2009.11.015. Chem Biol. 2009. PMID: 20064438 Free PMC article.

3

Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites.

Geurink PP, Liu N, Spaans MP, Downey SL, van den Nieuwendijk AM, van der Marel GA, Kisselev AF, Florea BI, Overkleeft HS. Geurink PP, et al. Among authors: downey sl. J Med Chem. 2010 Mar 11;53(5):2319-23. doi: 10.1021/jm9015685. J Med Chem. 2010. PMID: 20131905 Free PMC article.

4

Nature of pharmacophore influences active site specificity of proteasome inhibitors.

Screen M, Britton M, Downey SL, Verdoes M, Voges MJ, Blom AE, Geurink PP, Risseeuw MD, Florea BI, van der Linden WA, Pletnev AA, Overkleeft HS, Kisselev AF. Screen M, et al. Among authors: downey sl. J Biol Chem. 2010 Dec 17;285(51):40125-34. doi: 10.1074/jbc.M110.160606. Epub 2010 Oct 11. J Biol Chem. 2010. PMID: 20937826 Free PMC article.

5

Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib.

Mirabella AC, Pletnev AA, Downey SL, Florea BI, Shabaneh TB, Britton M, Verdoes M, Filippov DV, Overkleeft HS, Kisselev AF. Mirabella AC, et al. Among authors: downey sl. Chem Biol. 2011 May 27;18(5):608-18. doi: 10.1016/j.chembiol.2011.02.015. Chem Biol. 2011. PMID: 21609842 Free PMC article.

6

Cell-line-specific high background in the Proteasome-Glo assay of proteasome trypsin-like activity.

Wilkins OM, Downey SL, Weyburne ES, Williams DA, Mirabella AC, Overkleeft HS, Kisselev AF. Wilkins OM, et al. Among authors: downey sl. Anal Biochem. 2014 Apr 15;451:1-3. doi: 10.1016/j.ab.2014.01.009. Epub 2014 Jan 29. Anal Biochem. 2014. PMID: 24486333

7

Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib.

Shabaneh TB, Downey SL, Goddard AL, Screen M, Lucas MM, Eastman A, Kisselev AF. Shabaneh TB, et al. Among authors: downey sl. PLoS One. 2013;8(2):e56132. doi: 10.1371/journal.pone.0056132. Epub 2013 Feb 27. PLoS One. 2013. PMID: 23460792 Free PMC article.

8

Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ.

Cherukuri P, DeCastro AJ, Balboni AL, Downey SL, Liu JY, Hutchinson JA, DiRenzo J. Cherukuri P, et al. Among authors: downey sl. PLoS One. 2012;7(11):e50066. doi: 10.1371/journal.pone.0050066. Epub 2012 Nov 16. PLoS One. 2012. PMID: 23166821 Free PMC article.

9

Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells.

Allaway RJ, Wood MD, Downey SL, Bouley SJ, Traphagen NA, Wells JD, Batra J, Melancon SN, Ringelberg C, Seibel W, Ratner N, Sanchez Y. Allaway RJ, et al. Among authors: downey sl. Oncotarget. 2017 Jul 18;9(22):15860-15875. doi: 10.18632/oncotarget.19335. eCollection 2018 Mar 23. Oncotarget. 2017. PMID: 29662612 Free PMC article.

10

Dimeric W3SO3 cluster complexes: synthesis, characterization, and potential applications as X-ray contrast agents.

Yu SB, Droege M, Downey S, Segal B, Newcomb W, Sanderson T, Crofts S, Suravajjala S, Bacon E, Earley W, Delecki D, Watson AD. Yu SB, et al. Inorg Chem. 2001 Mar 26;40(7):1576-81. doi: 10.1021/ic0001053. Inorg Chem. 2001. PMID: 11261967

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