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NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation.
Kuosmanen SM, Kansanen E, Kaikkonen MU, Sihvola V, Pulkkinen K, Jyrkkänen HK, Tuoresmäki P, Hartikainen J, Hippeläinen M, Kokki H, Tavi P, Heikkinen S, Levonen AL. Kuosmanen SM, et al. Among authors: tavi p. Nucleic Acids Res. 2018 Feb 16;46(3):1124-1138. doi: 10.1093/nar/gkx1155. Nucleic Acids Res. 2018. PMID: 29161413 Free PMC article.
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.
Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Felszeghy S, et al. Among authors: tavi p. Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14. Redox Biol. 2019. PMID: 30253279 Free PMC article.
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma.
Pölönen P, Jawahar Deen A, Leinonen HM, Jyrkkänen HK, Kuosmanen S, Mononen M, Jain A, Tuomainen T, Pasonen-Seppänen S, Hartikainen JM, Mannermaa A, Nykter M, Tavi P, Johansen T, Heinäniemi M, Levonen AL. Pölönen P, et al. Among authors: tavi p. Oncogene. 2019 Dec;38(50):7473-7490. doi: 10.1038/s41388-019-0956-6. Epub 2019 Aug 23. Oncogene. 2019. PMID: 31444413
NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli.
Linna-Kuosmanen S, Tomas Bosch V, Moreau PR, Bouvy-Liivrand M, Niskanen H, Kansanen E, Kivelä A, Hartikainen J, Hippeläinen M, Kokki H, Tavi P, Levonen AL, Kaikkonen MU. Linna-Kuosmanen S, et al. Among authors: tavi p. Cardiovasc Res. 2021 Apr 23;117(5):1339-1357. doi: 10.1093/cvr/cvaa219. Cardiovasc Res. 2021. PMID: 32683448 Free PMC article.
WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.
Moilanen AM, Rysä J, Kaikkonen L, Karvonen T, Mustonen E, Serpi R, Szabó Z, Tenhunen O, Bagyura Z, Näpänkangas J, Ohukainen P, Tavi P, Kerkelä R, Leósdóttir M, Wahlstrand B, Hedner T, Melander O, Ruskoaho H. Moilanen AM, et al. Among authors: tavi p. PLoS One. 2015 Apr 27;10(4):e0124907. doi: 10.1371/journal.pone.0124907. eCollection 2015. PLoS One. 2015. PMID: 25915632 Free PMC article.
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