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PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine.
Lima IV, Campos AC, Miranda AS, Vieira ÉL, Amaral-Martins F, Vago JP, Santos RP, Sousa LP, Vieira LB, Teixeira MM, Fiebich BL, Moraes MF, Teixeira AL, de Oliveira AC. Lima IV, et al. Among authors: moraes mf. Exp Neurol. 2015 May;267:123-34. doi: 10.1016/j.expneurol.2015.02.021. Epub 2015 Mar 5. Exp Neurol. 2015. PMID: 25749189
Wistar Audiogenic Rats (WAR) exhibit altered levels of cytokines and brain-derived neurotrophic factor following audiogenic seizures.
de Souza Bernardino TC, Teixeira AL, Miranda AS, Guidine PM, Rezende G, Doretto MC, Castro GP, Drummond L, Moraes MF, Tito PA, de Oliveira AC, Reis HJ. de Souza Bernardino TC, et al. Among authors: moraes mf. Neurosci Lett. 2015 Jun 15;597:154-8. doi: 10.1016/j.neulet.2015.04.046. Epub 2015 Apr 30. Neurosci Lett. 2015. PMID: 25936592
The 5-lipoxygenase (5-LOX) Inhibitor Zileuton Reduces Inflammation and Infarct Size with Improvement in Neurological Outcome Following Cerebral Ischemia.
Silva BC, de Miranda AS, Rodrigues FG, Silveira AL, Resende GH, Moraes MF, de Oliveira AC, Parreiras PM, Barcelos Lda S, Teixeira MM, Machado FS, Teixeira AL, Rachid MA. Silva BC, et al. Among authors: moraes mf. Curr Neurovasc Res. 2015;12(4):398-403. doi: 10.2174/1567202612666150812150606. Curr Neurovasc Res. 2015. PMID: 26265153
Cannabidiol anticonvulsant effect is mediated by the PI3Kγ pathway.
Lima IVA, Bellozi PMQ, Batista EM, Vilela LR, Brandão IL, Ribeiro FM, Moraes MFD, Moreira FA, de Oliveira ACP. Lima IVA, et al. Neuropharmacology. 2020 Oct 1;176:108156. doi: 10.1016/j.neuropharm.2020.108156. Epub 2020 Jun 20. Neuropharmacology. 2020. PMID: 32574650
Cannabidiol effect in pentylenetetrazole-induced seizures depends on PI3K.
de Assis Lima IV, Pinto HPP, Bellozi PMQ, da Silva MCM, Vilela LR, Moreira FA, Moraes MFD, de Oliveira ACP. de Assis Lima IV, et al. Among authors: moraes mfd. Pharmacol Rep. 2022 Oct;74(5):1099-1106. doi: 10.1007/s43440-022-00391-y. Epub 2022 Sep 16. Pharmacol Rep. 2022. PMID: 36112318
148 results