Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

595 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.
Jeon AH, Böhm C, Chen F, Huo H, Ruan X, Ren CH, Ho K, Qamar S, Mathews PM, Fraser PE, Mount HT, St George-Hyslop P, Schmitt-Ulms G. Jeon AH, et al. Among authors: bohm c. J Biol Chem. 2013 May 24;288(21):15352-66. doi: 10.1074/jbc.M112.441840. Epub 2013 Apr 15. J Biol Chem. 2013. PMID: 23589300 Free PMC article.
Structural biology of presenilin 1 complexes.
Li Y, Bohm C, Dodd R, Chen F, Qamar S, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH. Li Y, et al. Among authors: bohm c. Mol Neurodegener. 2014 Dec 18;9:59. doi: 10.1186/1750-1326-9-59. Mol Neurodegener. 2014. PMID: 25523933 Free PMC article. Review.
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.
Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P. Rogaeva E, et al. Among authors: bohm c. Nat Genet. 2007 Feb;39(2):168-77. doi: 10.1038/ng1943. Epub 2007 Jan 14. Nat Genet. 2007. PMID: 17220890 Free PMC article.
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes.
Pardossi-Piquard R, Yang SP, Kanemoto S, Gu Y, Chen F, Böhm C, Sevalle J, Li T, Wong PC, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. Pardossi-Piquard R, et al. Among authors: bohm c. J Biol Chem. 2009 Jun 12;284(24):16298-16307. doi: 10.1074/jbc.M109.000067. Epub 2009 Apr 15. J Biol Chem. 2009. PMID: 19369254 Free PMC article.
TMP21 transmembrane domain regulates gamma-secretase cleavage.
Pardossi-Piquard R, Böhm C, Chen F, Kanemoto S, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. Pardossi-Piquard R, et al. Among authors: bohm c. J Biol Chem. 2009 Oct 16;284(42):28634-41. doi: 10.1074/jbc.M109.059345. Epub 2009 Aug 25. J Biol Chem. 2009. PMID: 19710022 Free PMC article.
Vigilin interacts with signal peptide peptidase.
Lu SH, Jeon AH, Schmitt-Ulms G, Qamar S, Dodd R, McDonald B, Li Y, Meadows W, Cox K, Bohm C, Chen F, Fraser P, George-Hyslop PS. Lu SH, et al. Among authors: bohm c. Proteome Sci. 2012 May 18;10(1):33. doi: 10.1186/1477-5956-10-33. Proteome Sci. 2012. PMID: 22607704 Free PMC article.
Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.
Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, Johnson CM, Farrer LA, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH. Li Y, et al. Among authors: bohm c. Structure. 2014 Jan 7;22(1):125-35. doi: 10.1016/j.str.2013.09.018. Epub 2013 Nov 7. Structure. 2014. PMID: 24210759 Free PMC article.
Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway.
Zhang Y, Zhang Y, Aman Y, Ng CT, Chau WH, Zhang Z, Yue M, Bohm C, Jia Y, Li S, Yuan Q, Griffin J, Chiu K, Wong DSM, Wang B, Jin D, Rogaeva E, Fraser PE, Fang EF, St George-Hyslop P, Song YQ. Zhang Y, et al. Among authors: bohm c. Brain. 2021 Oct 22;144(9):2759-2770. doi: 10.1093/brain/awab134. Brain. 2021. PMID: 34428276
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P. Chen F, et al. Among authors: bohm c. Nature. 2006 Apr 27;440(7088):1208-12. doi: 10.1038/nature04667. Nature. 2006. PMID: 16641999
595 results