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Therapeutic opportunities within the DNA damage response.
Pearl LH, Schierz AC, Ward SE, Al-Lazikani B, Pearl FM. Pearl LH, et al. Among authors: pearl fm. Nat Rev Cancer. 2015 Mar;15(3):166-80. doi: 10.1038/nrc3891. Nat Rev Cancer. 2015. PMID: 25709118 Free article. Review.
MoKCa database--mutations of kinases in cancer.
Richardson CJ, Gao Q, Mitsopoulous C, Zvelebil M, Pearl LH, Pearl FM. Richardson CJ, et al. Among authors: pearl lh, pearl fm. Nucleic Acids Res. 2009 Jan;37(Database issue):D824-31. doi: 10.1093/nar/gkn832. Epub 2008 Nov 5. Nucleic Acids Res. 2009. PMID: 18986996 Free PMC article.
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW. Hornyak P, et al. Among authors: pearl lh. Biochem J. 2016 Jul 1;473(13):1869-79. doi: 10.1042/BCJ20160180. Epub 2016 Apr 20. Biochem J. 2016. PMID: 27099339 Free PMC article.
Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.
Densham RM, Garvin AJ, Stone HR, Strachan J, Baldock RA, Daza-Martin M, Fletcher A, Blair-Reid S, Beesley J, Johal B, Pearl LH, Neely R, Keep NH, Watts FZ, Morris JR. Densham RM, et al. Among authors: pearl lh. Nat Struct Mol Biol. 2016 Jul;23(7):647-55. doi: 10.1038/nsmb.3236. Epub 2016 May 30. Nat Struct Mol Biol. 2016. PMID: 27239795 Free PMC article.
235 results