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Biaryl polyamides as a new class of DNA quadruplex-binding ligands.
Rahman KM, Reszka AP, Gunaratnam M, Haider SM, Howard PW, Fox KR, Neidle S, Thurston DE. Rahman KM, et al. Among authors: thurston de. Chem Commun (Camb). 2009 Jul 21;(27):4097-9. doi: 10.1039/b902359c. Epub 2009 Jun 5. Chem Commun (Camb). 2009. PMID: 19568645
Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.
Antonow D, Kaliszczak M, Kang GD, Coffils M, Tiberghien AC, Cooper N, Barata T, Heidelberger S, James CH, Zloh M, Jenkins TC, Reszka AP, Neidle S, Guichard SM, Jodrell DI, Hartley JA, Howard PW, Thurston DE. Antonow D, et al. Among authors: thurston de. J Med Chem. 2010 Apr 8;53(7):2927-41. doi: 10.1021/jm901722v. J Med Chem. 2010. PMID: 20218628
A novel small-molecule inhibitor of IL-6 signalling.
Zinzalla G, Haque MR, Basu BP, Anderson J, Kaye SL, Haider S, Hasan F, Antonow D, Essex S, Rahman KM, Palmer J, Morgenstern D, Wilderspin AF, Neidle S, Thurston DE. Zinzalla G, et al. Among authors: thurston de. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7029-32. doi: 10.1016/j.bmcl.2010.09.117. Epub 2010 Sep 29. Bioorg Med Chem Lett. 2010. PMID: 21030257
The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus.
Rosado H, Rahman KM, Feuerbaum EA, Hinds J, Thurston DE, Taylor PW. Rosado H, et al. Among authors: thurston de. J Antimicrob Chemother. 2011 May;66(5):985-96. doi: 10.1093/jac/dkr044. Epub 2011 Mar 3. J Antimicrob Chemother. 2011. PMID: 21393142 Free PMC article.
131 results