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WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.
Boulter L, Guest RV, Kendall TJ, Wilson DH, Wojtacha D, Robson AJ, Ridgway RA, Samuel K, Van Rooijen N, Barry ST, Wigmore SJ, Sansom OJ, Forbes SJ. Boulter L, et al. Among authors: kendall tj. J Clin Invest. 2015 Mar 2;125(3):1269-85. doi: 10.1172/JCI76452. Epub 2015 Feb 17. J Clin Invest. 2015. PMID: 25689248 Free PMC article.
Hepatic progenitor cells of biliary origin with liver repopulation capacity.
Lu WY, Bird TG, Boulter L, Tsuchiya A, Cole AM, Hay T, Guest RV, Wojtacha D, Man TY, Mackinnon A, Ridgway RA, Kendall T, Williams MJ, Jamieson T, Raven A, Hay DC, Iredale JP, Clarke AR, Sansom OJ, Forbes SJ. Lu WY, et al. Nat Cell Biol. 2015 Aug;17(8):971-983. doi: 10.1038/ncb3203. Epub 2015 Jul 20. Nat Cell Biol. 2015. PMID: 26192438 Free PMC article.
Notch3 drives development and progression of cholangiocarcinoma.
Guest RV, Boulter L, Dwyer BJ, Kendall TJ, Man TY, Minnis-Lyons SE, Lu WY, Robson AJ, Gonzalez SF, Raven A, Wojtacha D, Morton JP, Komuta M, Roskams T, Wigmore SJ, Sansom OJ, Forbes SJ. Guest RV, et al. Among authors: kendall tj. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12250-12255. doi: 10.1073/pnas.1600067113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791012 Free PMC article.
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.
Ferreira-Gonzalez S, Lu WY, Raven A, Dwyer B, Man TY, O'Duibhir E, Lewis PJS, Campana L, Kendall TJ, Bird TG, Tarrats N, Acosta JC, Boulter L, Forbes SJ. Ferreira-Gonzalez S, et al. Among authors: kendall tj. Nat Commun. 2018 Mar 9;9(1):1020. doi: 10.1038/s41467-018-03299-5. Nat Commun. 2018. PMID: 29523787 Free PMC article.
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.
Jackstadt R, van Hooff SR, Leach JD, Cortes-Lavaud X, Lohuis JO, Ridgway RA, Wouters VM, Roper J, Kendall TJ, Roxburgh CS, Horgan PG, Nixon C, Nourse C, Gunzer M, Clark W, Hedley A, Yilmaz OH, Rashid M, Bailey P, Biankin AV, Campbell AD, Adams DJ, Barry ST, Steele CW, Medema JP, Sansom OJ. Jackstadt R, et al. Among authors: kendall tj. Cancer Cell. 2019 Sep 16;36(3):319-336.e7. doi: 10.1016/j.ccell.2019.08.003. Cancer Cell. 2019. PMID: 31526760 Free PMC article.
Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors.
Wilson DH, Jarman EJ, Mellin RP, Wilson ML, Waddell SH, Tsokkou P, Younger NT, Raven A, Bhalla SR, Noll ATR, Olde Damink SW, Schaap FG, Chen P, Bates DO, Banales JM, Dean CH, Henderson DJ, Sansom OJ, Kendall TJ, Boulter L. Wilson DH, et al. Among authors: kendall tj. Nat Commun. 2020 Jan 23;11(1):445. doi: 10.1038/s41467-020-14283-3. Nat Commun. 2020. PMID: 31974352 Free PMC article.
TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression.
Dwyer BJ, Jarman EJ, Gogoi-Tiwari J, Ferreira-Gonzalez S, Boulter L, Guest RV, Kendall TJ, Kurian D, Kilpatrick AM, Robson AJ, O'Duibhir E, Man TY, Campana L, Starkey Lewis PJ, Wigmore SJ, Olynyk JK, Ramm GA, Tirnitz-Parker JEE, Forbes SJ. Dwyer BJ, et al. Among authors: kendall tj. J Hepatol. 2021 Apr;74(4):860-872. doi: 10.1016/j.jhep.2020.11.018. Epub 2020 Nov 19. J Hepatol. 2021. PMID: 33221352 Free article.
88 results