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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263.
Nat Commun. 2015.
PMID: 25672491
Free PMC article.
Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors.
Roessler C, Nowak T, Pannek M, Gertz M, Nguyen GT, Scharfe M, Born I, Sippl W, Steegborn C, Schutkowski M.
Roessler C, et al. Among authors: pannek m.
Angew Chem Int Ed Engl. 2014 Sep 26;53(40):10728-32. doi: 10.1002/anie.201402679. Epub 2014 Aug 11.
Angew Chem Int Ed Engl. 2014.
PMID: 25111069
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Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.
Pannek M, Simic Z, Fuszard M, Meleshin M, Rotili D, Mai A, Schutkowski M, Steegborn C.
Pannek M, et al.
Nat Commun. 2017 Nov 15;8(1):1513. doi: 10.1038/s41467-017-01701-2.
Nat Commun. 2017.
PMID: 29138502
Free PMC article.
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Potent and Selective Inhibitors of Human Sirtuin 5.
Kalbas D, Liebscher S, Nowak T, Meleshin M, Pannek M, Popp C, Alhalabi Z, Bordusa F, Sippl W, Steegborn C, Schutkowski M.
Kalbas D, et al. Among authors: pannek m.
J Med Chem. 2018 Mar 22;61(6):2460-2471. doi: 10.1021/acs.jmedchem.7b01648. Epub 2018 Mar 12.
J Med Chem. 2018.
PMID: 29494161
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Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.
Rajabi N, Auth M, Troelsen KR, Pannek M, Bhatt DP, Fontenas M, Hirschey MD, Steegborn C, Madsen AS, Olsen CA.
Rajabi N, et al. Among authors: pannek m.
Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14836-14841. doi: 10.1002/anie.201709050. Epub 2017 Nov 2.
Angew Chem Int Ed Engl. 2017.
PMID: 29044784
Free PMC article.
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From PARP1 to TNKS2 Inhibition: A Structure-Based Approach.
Tomassi S, Pfahler J, Mautone N, Rovere A, Esposito C, Passeri D, Pellicciari R, Novellino E, Pannek M, Steegborn C, Paiardini A, Mai A, Rotili D.
Tomassi S, et al. Among authors: pannek m.
ACS Med Chem Lett. 2020 Feb 3;11(5):862-868. doi: 10.1021/acsmedchemlett.9b00654. eCollection 2020 May 14.
ACS Med Chem Lett. 2020.
PMID: 32435397
Free PMC article.
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Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.
Pannek M, Alhalabi Z, Tomaselli D, Menna M, Fiorentino F, Robaa D, Weyand M, Puhlmann M, Tomassi S, Barreca F, Tafani M, Zaganjor E, Haigis MC, Sippl W, Rotili D, Mai A, Steegborn C.
Pannek M, et al.
J Med Chem. 2024 Feb 8;67(3):1843-1860. doi: 10.1021/acs.jmedchem.3c01496. Epub 2024 Jan 22.
J Med Chem. 2024.
PMID: 38253001
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CE methods for charge variant analysis of mAbs and complex format biotherapeutics.
Meudt M, Pannek M, Glogowski N, Higel F, Thanisch K, Knape MJ.
Meudt M, et al. Among authors: pannek m.
Electrophoresis. 2024 Jan 17. doi: 10.1002/elps.202300170. Online ahead of print.
Electrophoresis. 2024.
PMID: 38233206
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