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Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase.
Guzman JD, Pesnot T, Barrera DA, Davies HM, McMahon E, Evangelopoulos D, Mortazavi PN, Munshi T, Maitra A, Lamming ED, Angell R, Gershater MC, Redmond JM, Needham D, Ward JM, Cuca LE, Hailes HC, Bhakta S. Guzman JD, et al. Among authors: evangelopoulos d. J Antimicrob Chemother. 2015;70(6):1691-703. doi: 10.1093/jac/dkv010. Epub 2015 Feb 4. J Antimicrob Chemother. 2015. PMID: 25656411 Free PMC article.
Anti-tubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis.
Guzman JD, Gupta A, Evangelopoulos D, Basavannacharya C, Pabon LC, Plazas EA, Muñoz DR, Delgado WA, Cuca LE, Ribon W, Gibbons S, Bhakta S. Guzman JD, et al. Among authors: evangelopoulos d. J Antimicrob Chemother. 2010 Oct;65(10):2101-7. doi: 10.1093/jac/dkq313. Epub 2010 Aug 18. J Antimicrob Chemother. 2010. PMID: 20719764
Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics.
Guzman JD, Wube A, Evangelopoulos D, Gupta A, Hüfner A, Basavannacharya C, Rahman MM, Thomaschitz C, Bauer R, McHugh TD, Nobeli I, Prieto JM, Gibbons S, Bucar F, Bhakta S. Guzman JD, et al. Among authors: evangelopoulos d. J Antimicrob Chemother. 2011 Aug;66(8):1766-72. doi: 10.1093/jac/dkr203. Epub 2011 May 28. J Antimicrob Chemother. 2011. PMID: 21622974 Free PMC article.
Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis.
Maitra A, Evangelopoulos D, Chrzastek A, Martin LT, Hanrath A, Chapman E, Hailes HC, Lipman M, McHugh TD, Waddell SJ, Bhakta S. Maitra A, et al. Among authors: evangelopoulos d. J Antimicrob Chemother. 2020 Nov 1;75(11):3194-3201. doi: 10.1093/jac/dkaa307. J Antimicrob Chemother. 2020. PMID: 32790867 Free PMC article.
Antimycobacterials from lovage root (Ligusticum officinale Koch).
Guzman JD, Evangelopoulos D, Gupta A, Prieto JM, Gibbons S, Bhakta S. Guzman JD, et al. Among authors: evangelopoulos d. Phytother Res. 2013 Jul;27(7):993-8. doi: 10.1002/ptr.4823. Epub 2012 Aug 16. Phytother Res. 2013. PMID: 22899555
Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria.
Bhakta S, Scalacci N, Maitra A, Brown AK, Dasugari S, Evangelopoulos D, McHugh TD, Mortazavi PN, Twist A, Petricci E, Manetti F, Castagnolo D. Bhakta S, et al. Among authors: evangelopoulos d. J Med Chem. 2016 Mar 24;59(6):2780-93. doi: 10.1021/acs.jmedchem.6b00031. Epub 2016 Mar 8. J Med Chem. 2016. PMID: 26907951 Free article.
149 results