Lewin-Koh SC - Search Results

1

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.

Fuji RN, Flagella M, Baca M, Baptista MA, Brodbeck J, Chan BK, Fiske BK, Honigberg L, Jubb AM, Katavolos P, Lee DW, Lewin-Koh SC, Lin T, Liu X, Liu S, Lyssikatos JP, O'Mahony J, Reichelt M, Roose-Girma M, Sheng Z, Sherer T, Smith A, Solon M, Sweeney ZK, Tarrant J, Urkowitz A, Warming S, Yaylaoglu M, Zhang S, Zhu H, Estrada AA, Watts RJ. Fuji RN, et al. Among authors: lewin koh sc. Sci Transl Med. 2015 Feb 4;7(273):273ra15. doi: 10.1126/scitranslmed.aaa3634. Sci Transl Med. 2015. PMID: 25653221

2

Development of a safety biomarker signature to detect hepatic sinusoidal dilation associated with an anti-DLL4 biotherapeutic.

Tarrant JM, Lewin-Koh SC, Lewin-Koh N. Tarrant JM, et al. Among authors: lewin koh sc. Biomarkers. 2014 Aug;19(5):391-401. doi: 10.3109/1354750X.2014.919026. Epub 2014 May 19. Biomarkers. 2014. PMID: 24842386

3

Comparative evaluation of 11 in silico models for the prediction of small molecule mutagenicity: role of steric hindrance and electron-withdrawing groups.

Ford KA, Ryslik G, Chan BK, Lewin-Koh SC, Almeida D, Stokes M, Gomez SR. Ford KA, et al. Among authors: lewin koh sc. Toxicol Mech Methods. 2017 Jan;27(1):24-35. doi: 10.1080/15376516.2016.1174761. Epub 2016 Nov 4. Toxicol Mech Methods. 2017. PMID: 27813437

4

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

Diaz D, Allamneni K, Tarrant JM, Lewin-Koh SC, Pai R, Dhawan P, Cain GR, Kozlowski C, Hiraragi H, La N, Hartley DP, Ding X, Dean BJ, Bheddah S, Dambach DM. Diaz D, et al. Among authors: lewin koh sc. Toxicol Sci. 2012 Jan;125(1):187-95. doi: 10.1093/toxsci/kfr263. Epub 2011 Oct 5. Toxicol Sci. 2012. PMID: 21976371

5

Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology.

Erickson RI, Tarrant J, Cain G, Lewin-Koh SC, Dybdal N, Wong H, Blackwood E, West K, Steigerwalt R, Mamounas M, Flygare JA, Amemiya K, Dambach D, Fairbrother WJ, Diaz D. Erickson RI, et al. Among authors: lewin koh sc. Toxicol Sci. 2013 Jan;131(1):247-58. doi: 10.1093/toxsci/kfs265. Epub 2012 Sep 5. Toxicol Sci. 2013. PMID: 22956632

6

Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.

Erickson RI, Schutt LK, Tarrant JM, McDowell M, Liu L, Johnson AR, Lewin-Koh SC, Hedehus M, Ross J, Carano RA, Staflin K, Zhong F, Crawford JJ, Zhong S, Reif K, Katewa A, Wong H, Young WB, Dambach DM, Misner DL. Erickson RI, et al. Among authors: lewin koh sc. J Pharmacol Exp Ther. 2017 Jan;360(1):226-238. doi: 10.1124/jpet.116.236224. Epub 2016 Nov 7. J Pharmacol Exp Ther. 2017. PMID: 27821712

7

Influence of the compound selection process on the performance of human clearance prediction methods.

Wong H, Lewin-Koh SC, Theil FP, Hop CE. Wong H, et al. J Pharm Sci. 2012 Feb;101(2):509-15. doi: 10.1002/jps.22786. Epub 2011 Oct 4. J Pharm Sci. 2012. PMID: 21976152

8

Strategies to compare clinical antitherapeutic antibody data when changing assay platforms: a case study.

Qiu ZJ, Ying Y, Lewin-Koh SC, Coleman D, Brignoli S, Hendricks R, Siguenza P, Quarmby V, Fischer SK, Song A. Qiu ZJ, et al. Among authors: lewin koh sc. Bioanalysis. 2015;7(14):1775-83. doi: 10.4155/bio.15.91. Bioanalysis. 2015. PMID: 26270784

9

Reorienting the Fab domains of trastuzumab results in potent HER2 activators.

Scheer JM, Sandoval W, Elliott JM, Shao L, Luis E, Lewin-Koh SC, Schaefer G, Vandlen R. Scheer JM, et al. Among authors: lewin koh sc. PLoS One. 2012;7(12):e51817. doi: 10.1371/journal.pone.0051817. Epub 2012 Dec 20. PLoS One. 2012. PMID: 23284778 Free PMC article.

10

A novel homogeneous Biotin-digoxigenin based assay for the detection of human anti-therapeutic antibodies in autoimmune serum.

Qiu ZJ, Ying Y, Fox M, Peng K, Lewin-Koh SC, Coleman D, Good J, Lowe J, Rahman A, Yang J, Jiang J, Quarmby V, Song A. Qiu ZJ, et al. J Immunol Methods. 2010 Oct 31;362(1-2):101-11. doi: 10.1016/j.jim.2010.09.013. Epub 2010 Sep 22. J Immunol Methods. 2010. PMID: 20868690

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