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Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985.
Elgersma RC, Coumans RG, Huijbregts T, Menge WM, Joosten JA, Spijker HJ, de Groot FM, van der Lee MM, Ubink R, van den Dobbelsteen DJ, Egging DF, Dokter WH, Verheijden GF, Lemmens JM, Timmers CM, Beusker PH. Elgersma RC, et al. Among authors: coumans rg. Mol Pharm. 2015 Jun 1;12(6):1813-35. doi: 10.1021/mp500781a. Epub 2015 Feb 18. Mol Pharm. 2015. PMID: 25635711
Preclinical profile of the HER2-targeting ADC SYD983/SYD985: introduction of a new duocarmycin-based linker-drug platform.
Dokter W, Ubink R, van der Lee M, van der Vleuten M, van Achterberg T, Jacobs D, Loosveld E, van den Dobbelsteen D, Egging D, Mattaar E, Groothuis P, Beusker P, Coumans R, Elgersma R, Menge W, Joosten J, Spijker H, Huijbregts T, de Groot V, Eppink M, de Roo G, Verheijden G, Timmers M. Dokter W, et al. Mol Cancer Ther. 2014 Nov;13(11):2618-29. doi: 10.1158/1535-7163.MCT-14-0040-T. Epub 2014 Sep 4. Mol Cancer Ther. 2014. PMID: 25189543
A Platform for the Generation of Site-Specific Antibody-Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines.
Coumans RGE, Ariaans GJA, Spijker HJ, Renart Verkerk P, Beusker PH, Kokke BPA, Schouten J, Blomenröhr M, van der Lee MMC, Groothuis PG, Ubink R, Dokter WHA, Timmers CM. Coumans RGE, et al. Bioconjug Chem. 2020 Sep 16;31(9):2136-2146. doi: 10.1021/acs.bioconjchem.0c00337. Epub 2020 Aug 25. Bioconjug Chem. 2020. PMID: 32697078
Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody-Drug Conjugate.
Groothuis PG, Jacobs DCH, Hermens IAT, Damming D, Berentsen K, Mattaar-Hepp E, Stokman MEM, Boekel TV, Rouwette M, van der Vleuten MAJ, Sesink A, Dijcks FA, Coumans RGE, Schouten J, Glaudemans DH, Wijk DV, Blomenröhr M, Kappers WA, Ubink R, van der Lee MMC, Dokter WHA. Groothuis PG, et al. Among authors: coumans rge. Mol Cancer Ther. 2023 Jun 1;22(6):765-777. doi: 10.1158/1535-7163.MCT-22-0596. Mol Cancer Ther. 2023. PMID: 37042205 Free PMC article.
Molecular recognition and self-assembly special feature: Squaring cooperative binding circles.
Deutman AB, Monnereau C, Moalin M, Coumans RG, Veling N, Coenen M, Smits JM, de Gelder R, Elemans JA, Ercolani G, Nolte RJ, Rowan AE. Deutman AB, et al. Among authors: coumans rg. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10471-6. doi: 10.1073/pnas.0810145106. Epub 2009 May 21. Proc Natl Acad Sci U S A. 2009. PMID: 19470643 Free PMC article.
Allosterically driven multicomponent assembly.
Thordarson P, Coumans RG, Elemans JA, Thomassen PJ, Visser J, Rowan AE, Nolte RJ. Thordarson P, et al. Among authors: coumans rg. Angew Chem Int Ed Engl. 2004 Sep 13;43(36):4755-9. doi: 10.1002/anie.200460398. Angew Chem Int Ed Engl. 2004. PMID: 15366078 No abstract available.
Interlocked porphyrin switches.
Coumans RG, Elemans JA, Rowan AE, Nolte RJ. Coumans RG, et al. Chemistry. 2013 Jun 10;19(24):7758-70. doi: 10.1002/chem.201203983. Epub 2013 Apr 29. Chemistry. 2013. PMID: 23629971
12 results