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A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth.
Neuropharmacology. 2015 May;92:146-57. doi: 10.1016/j.neuropharm.2015.01.004. Epub 2015 Jan 14.
Neuropharmacology. 2015.
PMID: 25596491
Discovery of N-arylalkyl-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide derivatives as HCV NS5B polymerase inhibitors.
Deore RR, Chen GS, Chang PT, Chern TR, Lai SY, Chuang MH, Lin JH, Kung FL, Chen CS, Chiou CT, Chern JW.
Deore RR, et al.
ChemMedChem. 2012 May;7(5):850-60. doi: 10.1002/cmdc.201200058. Epub 2012 Mar 1.
ChemMedChem. 2012.
PMID: 22383290
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2-hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid with inbuilt β-N-hydroxy-γ-keto-acid pharmacophore as HCV NS5B polymerase inhibitors.
Deore RR, Chen GS, Chen CS, Chang PT, Chuang MH, Chern TR, Wang HC, Chern JW.
Deore RR, et al.
Curr Med Chem. 2012;19(4):613-24. doi: 10.2174/092986712798918833.
Curr Med Chem. 2012.
PMID: 22204334
Review.
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NS5B RNA dependent RNA polymerase inhibitors: the promising approach to treat hepatitis C virus infections.
Deore RR, Chern JW.
Deore RR, et al.
Curr Med Chem. 2010;17(32):3806-26. doi: 10.2174/092986710793205471.
Curr Med Chem. 2010.
PMID: 20858218
Review.
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