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Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A.
Kosmidis G, Veerman CC, Casini S, Verkerk AO, van de Pas S, Bellin M, Wilde AA, Mummery CL, Bezzina CR. Kosmidis G, et al. Circ Arrhythm Electrophysiol. 2016 Nov;9(11):e004227. doi: 10.1161/CIRCEP.116.004227. Circ Arrhythm Electrophysiol. 2016. PMID: 27784737
Switch From Fetal to Adult SCN5A Isoform in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Unmasks the Cellular Phenotype of a Conduction Disease-Causing Mutation.
Veerman CC, Mengarelli I, Lodder EM, Kosmidis G, Bellin M, Zhang M, Dittmann S, Guan K, Wilde AAM, Schulze-Bahr E, Greber B, Bezzina CR, Verkerk AO. Veerman CC, et al. Among authors: kosmidis g. J Am Heart Assoc. 2017 Jul 24;6(7):e005135. doi: 10.1161/JAHA.116.005135. J Am Heart Assoc. 2017. PMID: 28739862 Free PMC article.
Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro--correlation between contraction force and electrophysiology.
Ribeiro MC, Tertoolen LG, Guadix JA, Bellin M, Kosmidis G, D'Aniello C, Monshouwer-Kloots J, Goumans MJ, Wang YL, Feinberg AW, Mummery CL, Passier R. Ribeiro MC, et al. Among authors: kosmidis g. Biomaterials. 2015 May;51:138-150. doi: 10.1016/j.biomaterials.2015.01.067. Epub 2015 Feb 18. Biomaterials. 2015. PMID: 25771005
Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function.
Birket MJ, Ribeiro MC, Kosmidis G, Ward D, Leitoguinho AR, van de Pol V, Dambrot C, Devalla HD, Davis RP, Mastroberardino PG, Atsma DE, Passier R, Mummery CL. Birket MJ, et al. Among authors: kosmidis g. Cell Rep. 2015 Oct 27;13(4):733-745. doi: 10.1016/j.celrep.2015.09.025. Epub 2015 Oct 17. Cell Rep. 2015. PMID: 26489474 Free PMC article.
TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT.
Devalla HD, Gélinas R, Aburawi EH, Beqqali A, Goyette P, Freund C, Chaix MA, Tadros R, Jiang H, Le Béchec A, Monshouwer-Kloots JJ, Zwetsloot T, Kosmidis G, Latour F, Alikashani A, Hoekstra M, Schlaepfer J, Mummery CL, Stevenson B, Kutalik Z, de Vries AA, Rivard L, Wilde AA, Talajic M, Verkerk AO, Al-Gazali L, Rioux JD, Bhuiyan ZA, Passier R. Devalla HD, et al. Among authors: kosmidis g. EMBO Mol Med. 2016 Dec 1;8(12):1390-1408. doi: 10.15252/emmm.201505719. Print 2016 Dec. EMBO Mol Med. 2016. PMID: 27861123 Free PMC article.
Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia.
Campostrini G, Kosmidis G, Ward-van Oostwaard D, Davis RP, Yiangou L, Ottaviani D, Veerman CC, Mei H, Orlova VV, Wilde AAM, Bezzina CR, Verkerk AO, Mummery CL, Bellin M. Campostrini G, et al. Among authors: kosmidis g. Cardiovasc Res. 2023 Mar 17;119(1):167-182. doi: 10.1093/cvr/cvac059. Cardiovasc Res. 2023. PMID: 35394010 Free PMC article.
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