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The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.
Jaeger M, van der Lee R, Cheng SC, Johnson MD, Kumar V, Ng A, Plantinga TS, Smeekens SP, Oosting M, Wang X, Barchet W, Fitzgerald K, Joosten LAB, Perfect JR, Wijmenga C, van de Veerdonk FL, Huynen MA, Xavier RJ, Kullberg BJ, Netea MG. Jaeger M, et al. Among authors: barchet w. Eur J Clin Microbiol Infect Dis. 2015 May;34(5):963-974. doi: 10.1007/s10096-014-2309-2. Epub 2015 Jan 13. Eur J Clin Microbiol Infect Dis. 2015. PMID: 25579795 Free PMC article.
Approaching the RNA ligand for RIG-I?
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G. Schlee M, et al. Among authors: barchet w. Immunol Rev. 2009 Jan;227(1):66-74. doi: 10.1111/j.1600-065X.2008.00724.x. Immunol Rev. 2009. PMID: 19120476 Review.
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G. Schlee M, et al. Among authors: barchet w. Immunity. 2009 Jul 17;31(1):25-34. doi: 10.1016/j.immuni.2009.05.008. Epub 2009 Jul 2. Immunity. 2009. PMID: 19576794 Free PMC article.
Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells.
Kübler K, tho Pesch C, Gehrke N, Riemann S, Dassler J, Coch C, Landsberg J, Wimmenauer V, Pölcher M, Rudlowski C, Tüting T, Kuhn W, Hartmann G, Barchet W. Kübler K, et al. Among authors: barchet w. Eur J Immunol. 2011 Oct;41(10):3028-39. doi: 10.1002/eji.201141555. Epub 2011 Aug 30. Eur J Immunol. 2011. PMID: 21728171 Free article.
RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids.
Abdullah Z, Schlee M, Roth S, Mraheil MA, Barchet W, Böttcher J, Hain T, Geiger S, Hayakawa Y, Fritz JH, Civril F, Hopfner KP, Kurts C, Ruland J, Hartmann G, Chakraborty T, Knolle PA. Abdullah Z, et al. Among authors: barchet w. EMBO J. 2012 Nov 5;31(21):4153-64. doi: 10.1038/emboj.2012.274. Epub 2012 Oct 12. EMBO J. 2012. PMID: 23064150 Free PMC article.
Endothelial RIG-I activation impairs endothelial function.
Asdonk T, Motz I, Werner N, Coch C, Barchet W, Hartmann G, Nickenig G, Zimmer S. Asdonk T, et al. Among authors: barchet w. Biochem Biophys Res Commun. 2012 Mar 30;420(1):66-71. doi: 10.1016/j.bbrc.2012.02.116. Epub 2012 Feb 28. Biochem Biophys Res Commun. 2012. PMID: 22402283
80 results