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Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action.
Artola M, Ruiz-Avila LB, Vergoñós A, Huecas S, Araujo-Bazán L, Martín-Fontecha M, Vázquez-Villa H, Turrado C, Ramírez-Aportela E, Hoegl A, Nodwell M, Barasoain I, Chacón P, Sieber SA, Andreu JM, López-Rodríguez ML. Artola M, et al. Among authors: huecas s. ACS Chem Biol. 2015 Mar 20;10(3):834-43. doi: 10.1021/cb500974d. Epub 2014 Dec 30. ACS Chem Biol. 2015. PMID: 25486266
The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation.
Andreu JM, Schaffner-Barbero C, Huecas S, Alonso D, Lopez-Rodriguez ML, Ruiz-Avila LB, Núñez-Ramírez R, Llorca O, Martín-Galiano AJ. Andreu JM, et al. Among authors: huecas s. J Biol Chem. 2010 May 7;285(19):14239-46. doi: 10.1074/jbc.M109.094722. Epub 2010 Mar 8. J Biol Chem. 2010. PMID: 20212044 Free PMC article.
Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.
Ruiz-Avila LB, Huecas S, Artola M, Vergoñós A, Ramírez-Aportela E, Cercenado E, Barasoain I, Vázquez-Villa H, Martín-Fontecha M, Chacón P, López-Rodríguez ML, Andreu JM. Ruiz-Avila LB, et al. Among authors: huecas s. ACS Chem Biol. 2013 Sep 20;8(9):2072-83. doi: 10.1021/cb400208z. Epub 2013 Jul 31. ACS Chem Biol. 2013. PMID: 23855511
Interactions of bacterial cell division protein FtsZ with C8-substituted guanine nucleotide inhibitors. A combined NMR, biochemical and molecular modeling perspective.
Marcelo F, Huecas S, Ruiz-Ávila LB, Cañada FJ, Perona A, Poveda A, Martín-Santamaría S, Morreale A, Jiménez-Barbero J, Andreu JM. Marcelo F, et al. Among authors: huecas s. J Am Chem Soc. 2013 Nov 6;135(44):16418-28. doi: 10.1021/ja405515r. Epub 2013 Oct 24. J Am Chem Soc. 2013. PMID: 24079270
The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors.
Artola M, Ruíz-Avila LB, Ramírez-Aportela E, Martínez RF, Araujo-Bazán L, Vázquez-Villa H, Martín-Fontecha M, Oliva MA, Martín-Galiano AJ, Chacón P, López-Rodríguez ML, Andreu JM, Huecas S. Artola M, et al. Among authors: huecas s. Chem Sci. 2017 Feb 1;8(2):1525-1534. doi: 10.1039/c6sc03792e. Epub 2016 Oct 21. Chem Sci. 2017. PMID: 28616148 Free PMC article.
28 results