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Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease.
Tamir S, Paddock ML, Darash-Yahana-Baram M, Holt SH, Sohn YS, Agranat L, Michaeli D, Stofleth JT, Lipper CH, Morcos F, Cabantchik IZ, Onuchic JN, Jennings PA, Mittler R, Nechushtai R. Tamir S, et al. Among authors: mittler r. Biochim Biophys Acta. 2015 Jun;1853(6):1294-315. doi: 10.1016/j.bbamcr.2014.10.014. Epub 2014 Oct 23. Biochim Biophys Acta. 2015. PMID: 25448035 Free article. Review.
ROS and redox signalling in the response of plants to abiotic stress.
Suzuki N, Koussevitzky S, Mittler R, Miller G. Suzuki N, et al. Among authors: mittler r. Plant Cell Environ. 2012 Feb;35(2):259-70. doi: 10.1111/j.1365-3040.2011.02336.x. Epub 2011 Jun 20. Plant Cell Environ. 2012. PMID: 21486305 Free article. Review.
Respiratory burst oxidases: the engines of ROS signaling.
Suzuki N, Miller G, Morales J, Shulaev V, Torres MA, Mittler R. Suzuki N, et al. Among authors: mittler r. Curr Opin Plant Biol. 2011 Dec;14(6):691-9. doi: 10.1016/j.pbi.2011.07.014. Epub 2011 Aug 19. Curr Opin Plant Biol. 2011. PMID: 21862390 Review.
Characterization of Arabidopsis NEET reveals an ancient role for NEET proteins in iron metabolism.
Nechushtai R, Conlan AR, Harir Y, Song L, Yogev O, Eisenberg-Domovich Y, Livnah O, Michaeli D, Rosen R, Ma V, Luo Y, Zuris JA, Paddock ML, Cabantchik ZI, Jennings PA, Mittler R. Nechushtai R, et al. Among authors: mittler r. Plant Cell. 2012 May;24(5):2139-54. doi: 10.1105/tpc.112.097634. Epub 2012 May 4. Plant Cell. 2012. PMID: 22562611 Free PMC article.
NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.
Sohn YS, Tamir S, Song L, Michaeli D, Matouk I, Conlan AR, Harir Y, Holt SH, Shulaev V, Paddock ML, Hochberg A, Cabanchick IZ, Onuchic JN, Jennings PA, Nechushtai R, Mittler R. Sohn YS, et al. Among authors: mittler r. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14676-81. doi: 10.1073/pnas.1313198110. Epub 2013 Aug 19. Proc Natl Acad Sci U S A. 2013. PMID: 23959881 Free PMC article.
ROS as key players in plant stress signalling.
Baxter A, Mittler R, Suzuki N. Baxter A, et al. Among authors: mittler r. J Exp Bot. 2014 Mar;65(5):1229-40. doi: 10.1093/jxb/ert375. Epub 2013 Nov 19. J Exp Bot. 2014. PMID: 24253197 Review.
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
Tamir S, Rotem-Bamberger S, Katz C, Morcos F, Hailey KL, Zuris JA, Wang C, Conlan AR, Lipper CH, Paddock ML, Mittler R, Onuchic JN, Jennings PA, Friedler A, Nechushtai R. Tamir S, et al. Among authors: mittler r. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5177-82. doi: 10.1073/pnas.1403770111. Epub 2014 Mar 25. Proc Natl Acad Sci U S A. 2014. PMID: 24706857 Free PMC article.
A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties.
Tamir S, Eisenberg-Domovich Y, Conlan AR, Stofleth JT, Lipper CH, Paddock ML, Mittler R, Jennings PA, Livnah O, Nechushtai R. Tamir S, et al. Among authors: mittler r. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1572-8. doi: 10.1107/S1399004714005458. Epub 2014 May 23. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24914968 Free PMC article.
318 results