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Page 1
Adamantyl analogues of paracetamol as potent analgesic drugs via inhibition of TRPA1.
Fresno N, Pérez-Fernández R, Goicoechea C, Alkorta I, Fernández-Carvajal A, de la Torre-Martínez R, Quirce S, Ferrer-Montiel A, Martín MI, Goya P, Elguero J. Fresno N, et al. PLoS One. 2014 Dec 1;9(12):e113841. doi: 10.1371/journal.pone.0113841. eCollection 2014. PLoS One. 2014. PMID: 25438056 Free PMC article.
Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity.
Balsera B, Mulet J, Sala S, Sala F, de la Torre-Martínez R, González-Rodríguez S, Plata A, Naesens L, Fernández-Carvajal A, Ferrer-Montiel A, Criado M, Pérez de Vega MJ, González-Muñiz R. Balsera B, et al. Among authors: de la torre martinez r. Eur J Med Chem. 2018 Jan 1;143:157-165. doi: 10.1016/j.ejmech.2017.10.083. Epub 2017 Nov 2. Eur J Med Chem. 2018. PMID: 29174812
1-(2',5'-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of α7 Nicotinic Receptors with Analgesic and Neuroprotective Activity.
Pérez de Vega MJ, Fernandez-Mendivil C, de la Torre Martínez R, González-Rodríguez S, Mullet J, Sala F, Sala S, Criado M, Moreno-Fernández S, Miguel M, Fernández-Carvajal A, Ferrer-Montiel A, López MG, González-Muñiz R. Pérez de Vega MJ, et al. Among authors: de la torre martinez r. ACS Chem Neurosci. 2019 Aug 21;10(8):3900-3909. doi: 10.1021/acschemneuro.9b00364. Epub 2019 Aug 2. ACS Chem Neurosci. 2019. PMID: 31322853 Free article.
De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators.
Bonache MÁ, Balsera B, López-Méndez B, Millet O, Brancaccio D, Gómez-Monterrey I, Carotenuto A, Pavone LM, Reille-Seroussi M, Gagey-Eilstein N, Vidal M, de la Torre-Martinez R, Fernández-Carvajal A, Ferrer-Montiel A, García-López MT, Martín-Martínez M, de Vega MJ, González-Muñiz R. Bonache MÁ, et al. ACS Comb Sci. 2014 May 12;16(5):250-8. doi: 10.1021/co500005x. Epub 2014 Apr 22. ACS Comb Sci. 2014. PMID: 24725184 Free article.
Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: a new target for a privileged structure.
Balsera B, Mulet J, Fernández-Carvajal A, de la Torre-Martínez R, Ferrer-Montiel A, Hernández-Jiménez JG, Estévez-Herrera J, Borges R, Freitas AE, López MG, García-López MT, González-Muñiz R, Pérez de Vega MJ, Valor LM, Svobodová L, Sala S, Sala F, Criado M. Balsera B, et al. Eur J Med Chem. 2014 Oct 30;86:724-39. doi: 10.1016/j.ejmech.2014.09.039. Epub 2014 Sep 16. Eur J Med Chem. 2014. PMID: 25232969
1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties.
Criado M, Balsera B, Mulet J, Sala S, Sala F, de la Torre-Martínez R, Fernández-Carvajal A, Ferrer-Montiel A, Moreno-Fernández S, Miguel M, Pérez de Vega MJ, González-Muñiz R. Criado M, et al. Among authors: de la torre martinez r. Future Med Chem. 2016 May;8(7):731-49. doi: 10.4155/fmc-2015-0001. Epub 2016 May 10. Future Med Chem. 2016. PMID: 27161515 Free article.
Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity.
Bonache MÁ, Martín-Escura C, de la Torre Martínez R, Medina A, González-Rodríguez S, Francesch A, Cuevas C, Roa AM, Fernández-Ballester G, Ferrer-Montiel A, Fernández-Carvajal A, González-Muñiz R. Bonache MÁ, et al. Among authors: de la torre martinez r. Sci Rep. 2020 Aug 25;10(1):14154. doi: 10.1038/s41598-020-70691-x. Sci Rep. 2020. PMID: 32843690 Free PMC article.
Phenylalanine-Derived β-Lactam TRPM8 Modulators. Configuration Effect on the Antagonist Activity.
Bonache MÁ, Llabrés PJ, Martín-Escura C, De la Torre-Martínez R, Medina-Peris A, Butrón L, Gómez-Monterrey I, Roa AM, Fernández-Ballester G, Ferrer-Montiel A, Fernández-Carvajal A, González-Muñiz R. Bonache MÁ, et al. Among authors: de la torre martinez r. Int J Mol Sci. 2021 Feb 27;22(5):2370. doi: 10.3390/ijms22052370. Int J Mol Sci. 2021. PMID: 33673444 Free PMC article.
β-Lactam TRPM8 Antagonist RGM8-51 Displays Antinociceptive Activity in Different Animal Models.
Martín-Escura C, Medina-Peris A, Spear LA, de la Torre Martínez R, Olivos-Oré LA, Barahona MV, González-Rodríguez S, Fernández-Ballester G, Fernández-Carvajal A, Artalejo AR, Ferrer-Montiel A, González-Muñiz R. Martín-Escura C, et al. Among authors: de la torre martinez r. Int J Mol Sci. 2022 Feb 28;23(5):2692. doi: 10.3390/ijms23052692. Int J Mol Sci. 2022. PMID: 35269831 Free PMC article.
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