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Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief.
Moriconi A, Cunha TM, Souza GR, Lopes AH, Cunha FQ, Carneiro VL, Pinto LG, Brandolini L, Aramini A, Bizzarri C, Bianchini G, Beccari AR, Fanton M, Bruno A, Costantino G, Bertini R, Galliera E, Locati M, Ferreira SH, Teixeira MM, Allegretti M. Moriconi A, et al. Among authors: souza gr. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16937-42. doi: 10.1073/pnas.1417365111. Epub 2014 Nov 10. Proc Natl Acad Sci U S A. 2014. PMID: 25385614 Free PMC article.
Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway.
Cunha TM, Roman-Campos D, Lotufo CM, Duarte HL, Souza GR, Verri WA Jr, Funez MI, Dias QM, Schivo IR, Domingues AC, Sachs D, Chiavegatto S, Teixeira MM, Hothersall JS, Cruz JS, Cunha FQ, Ferreira SH. Cunha TM, et al. Among authors: souza gr. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4442-7. doi: 10.1073/pnas.0914733107. Epub 2010 Feb 10. Proc Natl Acad Sci U S A. 2010. PMID: 20147620 Free PMC article.
Dual role of hydrogen sulfide in mechanical inflammatory hypernociception.
Cunha TM, Dal-Secco D, Verri WA Jr, Guerrero AT, Souza GR, Vieira SM, Lotufo CM, Neto AF, Ferreira SH, Cunha FQ. Cunha TM, et al. Among authors: souza gr. Eur J Pharmacol. 2008 Aug 20;590(1-3):127-35. doi: 10.1016/j.ejphar.2008.05.048. Epub 2008 Jun 7. Eur J Pharmacol. 2008. PMID: 18585702
Targeting endothelin ETA and ETB receptors inhibits antigen-induced neutrophil migration and mechanical hypernociception in mice.
Verri WA Jr, Cunha TM, Magro DA, Guerrero AT, Vieira SM, Carregaro V, Souza GR, Henriques Md, Ferreira SH, Cunha FQ. Verri WA Jr, et al. Among authors: souza gr. Naunyn Schmiedebergs Arch Pharmacol. 2009 Mar;379(3):271-9. doi: 10.1007/s00210-008-0360-1. Epub 2008 Oct 15. Naunyn Schmiedebergs Arch Pharmacol. 2009. PMID: 18854982
The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development.
Santa-Cecília FV, Ferreira DW, Guimaraes RM, Cecilio NT, Fonseca MM, Lopes AH, Davoli-Ferreira M, Kusuda R, Souza GR, Nachbur U, Alves-Filho JC, Teixeira MM, Zamboni DS, Cunha FQ, Cunha TM. Santa-Cecília FV, et al. Among authors: souza gr. Pain. 2019 Jan;160(1):102-116. doi: 10.1097/j.pain.0000000000001383. Pain. 2019. PMID: 30169421
Role of IL-18 in overt pain-like behaviour in mice.
Verri WA Jr, Cunha TM, Magro DA, Domingues AC, Vieira SM, Souza GR, Liew FY, Ferreira SH, Cunha FQ. Verri WA Jr, et al. Among authors: souza gr. Eur J Pharmacol. 2008 Jul 7;588(2-3):207-12. doi: 10.1016/j.ejphar.2008.04.010. Epub 2008 Apr 9. Eur J Pharmacol. 2008. PMID: 18511039
136 results