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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP. Chouchani ET, et al. Among authors: shattock mj. Nature. 2014 Nov 20;515(7527):431-435. doi: 10.1038/nature13909. Epub 2014 Nov 5. Nature. 2014. PMID: 25383517 Free PMC article.
Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat.
Robb EL, Gawel JM, Aksentijević D, Cochemé HM, Stewart TS, Shchepinova MM, Qiang H, Prime TA, Bright TP, James AM, Shattock MJ, Senn HM, Hartley RC, Murphy MP. Robb EL, et al. Among authors: shattock mj. Free Radic Biol Med. 2015 Dec;89:883-94. doi: 10.1016/j.freeradbiomed.2015.08.021. Epub 2015 Oct 8. Free Radic Biol Med. 2015. PMID: 26454075 Free article.
Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation.
Mansor LS, Mehta K, Aksentijevic D, Carr CA, Lund T, Cole MA, Le Page L, Sousa Fialho Mda L, Shattock MJ, Aasum E, Clarke K, Tyler DJ, Heather LC. Mansor LS, et al. Among authors: shattock mj. J Physiol. 2016 Jan 15;594(2):307-20. doi: 10.1113/JP271242. Epub 2015 Dec 20. J Physiol. 2016. PMID: 26574233 Free PMC article.
Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O, Rodriguez Cutillas P, Cuello F, Shattock MJ, Marber MS, Conte MR, Greenstein A, Greensmith DJ, Venetucci L, Timms JF, Eaton P. Scotcher J, et al. Among authors: shattock mj. Nat Commun. 2016 Oct 26;7:13187. doi: 10.1038/ncomms13187. Nat Commun. 2016. PMID: 27782102 Free PMC article.
Mechanism of succinate efflux upon reperfusion of the ischaemic heart.
Prag HA, Gruszczyk AV, Huang MM, Beach TE, Young T, Tronci L, Nikitopoulou E, Mulvey JF, Ascione R, Hadjihambi A, Shattock MJ, Pellerin L, Saeb-Parsy K, Frezza C, James AM, Krieg T, Murphy MP, Aksentijević D. Prag HA, et al. Among authors: shattock mj. Cardiovasc Res. 2021 Mar 21;117(4):1188-1201. doi: 10.1093/cvr/cvaa148. Cardiovasc Res. 2021. PMID: 32766828 Free PMC article.
144 results