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Page 1
Serine deprivation enhances antineoplastic activity of biguanides.
Gravel SP, Hulea L, Toban N, Birman E, Blouin MJ, Zakikhani M, Zhao Y, Topisirovic I, St-Pierre J, Pollak M. Gravel SP, et al. Among authors: topisirovic i. Cancer Res. 2014 Dec 15;74(24):7521-33. doi: 10.1158/0008-5472.CAN-14-2643-T. Epub 2014 Nov 6. Cancer Res. 2014. PMID: 25377470
Distinct perturbation of the translatome by the antidiabetic drug metformin.
Larsson O, Morita M, Topisirovic I, Alain T, Blouin MJ, Pollak M, Sonenberg N. Larsson O, et al. Among authors: topisirovic i. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8977-82. doi: 10.1073/pnas.1201689109. Epub 2012 May 18. Proc Natl Acad Sci U S A. 2012. PMID: 22611195 Free PMC article.
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies.
Alain T, Morita M, Fonseca BD, Yanagiya A, Siddiqui N, Bhat M, Zammit D, Marcus V, Metrakos P, Voyer LA, Gandin V, Liu Y, Topisirovic I, Sonenberg N. Alain T, et al. Among authors: topisirovic i. Cancer Res. 2012 Dec 15;72(24):6468-76. doi: 10.1158/0008-5472.CAN-12-2395. Epub 2012 Oct 24. Cancer Res. 2012. PMID: 23100465
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.
Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N. Morita M, et al. Among authors: topisirovic i. Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001. Cell Metab. 2013. PMID: 24206664 Free article.
Targeting the translation machinery in cancer.
Bhat M, Robichaud N, Hulea L, Sonenberg N, Pelletier J, Topisirovic I. Bhat M, et al. Among authors: topisirovic i. Nat Rev Drug Discov. 2015 Apr;14(4):261-78. doi: 10.1038/nrd4505. Epub 2015 Mar 6. Nat Rev Drug Discov. 2015. PMID: 25743081 Review.
SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.
Feng Y, Pinkerton AB, Hulea L, Zhang T, Davies MA, Grotegut S, Cheli Y, Yin H, Lau E, Kim H, De SK, Barile E, Pellecchia M, Bosenberg M, Li JL, James B, Hassig CA, Brown KM, Topisirovic I, Ronai ZA. Feng Y, et al. Among authors: topisirovic i. Cancer Res. 2015 Dec 15;75(24):5211-8. doi: 10.1158/0008-5472.CAN-15-0885. Epub 2015 Nov 24. Cancer Res. 2015. PMID: 26603897 Free PMC article.
Biomedical Potential of mTOR Modulation by Nanoparticles.
Hulea L, Markovic Z, Topisirovic I, Simmet T, Trajkovic V. Hulea L, et al. Among authors: topisirovic i. Trends Biotechnol. 2016 May;34(5):349-353. doi: 10.1016/j.tibtech.2016.01.005. Epub 2016 Feb 15. Trends Biotechnol. 2016. PMID: 26900005
nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.
Gandin V, Masvidal L, Hulea L, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA Jr, St-Pierre J, Pelletier J, Larsson O, Topisirovic I. Gandin V, et al. Among authors: topisirovic i. Genome Res. 2016 May;26(5):636-48. doi: 10.1101/gr.197566.115. Epub 2016 Mar 16. Genome Res. 2016. PMID: 26984228 Free PMC article.
133 results