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132 results

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Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.
De Stefano D, Villella VR, Esposito S, Tosco A, Sepe A, De Gregorio F, Salvadori L, Grassia R, Leone CA, De Rosa G, Maiuri MC, Pettoello-Mantovani M, Guido S, Bossi A, Zolin A, Venerando A, Pinna LA, Mehta A, Bona G, Kroemer G, Maiuri L, Raia V. De Stefano D, et al. Among authors: guido s. Autophagy. 2014;10(11):2053-74. doi: 10.4161/15548627.2014.973737. Autophagy. 2014. PMID: 25350163 Free PMC article. Clinical Trial.
Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa.
Luciani A, Villella VR, Vasaturo A, Giardino I, Pettoello-Mantovani M, Guido S, Cexus ON, Peake N, Londei M, Quaratino S, Maiuri L. Luciani A, et al. Among authors: guido s. Gut. 2010 Mar;59(3):311-9. doi: 10.1136/gut.2009.183608. Epub 2009 Dec 1. Gut. 2010. PMID: 19951908
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition.
Luciani A, Villella VR, Esposito S, Brunetti-Pierri N, Medina D, Settembre C, Gavina M, Pulze L, Giardino I, Pettoello-Mantovani M, D'Apolito M, Guido S, Masliah E, Spencer B, Quaratino S, Raia V, Ballabio A, Maiuri L. Luciani A, et al. Among authors: guido s. Nat Cell Biol. 2010 Sep;12(9):863-75. doi: 10.1038/ncb2090. Epub 2010 Aug 15. Nat Cell Biol. 2010. PMID: 20711182
Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator.
Luciani A, Villella VR, Esposito S, Gavina M, Russo I, Silano M, Guido S, Pettoello-Mantovani M, Carnuccio R, Scholte B, De Matteis A, Maiuri MC, Raia V, Luini A, Kroemer G, Maiuri L. Luciani A, et al. Among authors: guido s. Autophagy. 2012 Nov;8(11):1657-72. doi: 10.4161/auto.21483. Epub 2012 Aug 9. Autophagy. 2012. PMID: 22874563 Free PMC article.
Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator.
Villella VR, Esposito S, Bruscia EM, Vicinanza M, Cenci S, Guido S, Pettoello-Mantovani M, Carnuccio R, De Matteis MA, Luini A, Maiuri MC, Raia V, Kroemer G, Maiuri L. Villella VR, et al. Among authors: guido s. Cell Death Differ. 2013 Aug;20(8):1101-15. doi: 10.1038/cdd.2013.46. Epub 2013 May 17. Cell Death Differ. 2013. PMID: 23686137 Free PMC article.
A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR.
Tosco A, De Gregorio F, Esposito S, De Stefano D, Sana I, Ferrari E, Sepe A, Salvadori L, Buonpensiero P, Di Pasqua A, Grassia R, Leone CA, Guido S, De Rosa G, Lusa S, Bona G, Stoll G, Maiuri MC, Mehta A, Kroemer G, Maiuri L, Raia V. Tosco A, et al. Among authors: guido s. Cell Death Differ. 2016 Aug;23(8):1380-93. doi: 10.1038/cdd.2016.22. Epub 2016 Apr 1. Cell Death Differ. 2016. PMID: 27035618 Free PMC article. Clinical Trial.
A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR.
Tosco A, De Gregorio F, Esposito S, De Stefano D, Sana I, Ferrari E, Sepe A, Salvadori L, Buonpensiero P, Di Pasqua A, Grassia R, Leone CA, Guido S, De Rosa G, Lusa S, Bona G, Stoll G, Maiuri MC, Mehta A, Kroemer G, Maiuri L, Raia V. Tosco A, et al. Among authors: guido s. Cell Death Differ. 2017 Jul;24(7):1305. doi: 10.1038/cdd.2016.43. Epub 2016 Jul 22. Cell Death Differ. 2017. PMID: 27447111 Free PMC article.
132 results