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Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.
De Stefano D, Villella VR, Esposito S, Tosco A, Sepe A, De Gregorio F, Salvadori L, Grassia R, Leone CA, De Rosa G, Maiuri MC, Pettoello-Mantovani M, Guido S, Bossi A, Zolin A, Venerando A, Pinna LA, Mehta A, Bona G, Kroemer G, Maiuri L, Raia V. De Stefano D, et al. Among authors: esposito s. Autophagy. 2014;10(11):2053-74. doi: 10.4161/15548627.2014.973737. Autophagy. 2014. PMID: 25350163 Free PMC article. Clinical Trial.
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition.
Luciani A, Villella VR, Esposito S, Brunetti-Pierri N, Medina D, Settembre C, Gavina M, Pulze L, Giardino I, Pettoello-Mantovani M, D'Apolito M, Guido S, Masliah E, Spencer B, Quaratino S, Raia V, Ballabio A, Maiuri L. Luciani A, et al. Among authors: esposito s. Nat Cell Biol. 2010 Sep;12(9):863-75. doi: 10.1038/ncb2090. Epub 2010 Aug 15. Nat Cell Biol. 2010. PMID: 20711182
Cystic fibrosis: a disorder with defective autophagy.
Luciani A, Villella VR, Esposito S, Brunetti-Pierri N, Medina DL, Settembre C, Gavina M, Raia V, Ballabio A, Maiuri L. Luciani A, et al. Among authors: esposito s. Autophagy. 2011 Jan;7(1):104-6. doi: 10.4161/auto.7.1.13987. Epub 2011 Jan 1. Autophagy. 2011. PMID: 21048426
Nebulized hyaluronan ameliorates lung inflammation in cystic fibrosis mice.
Gavina M, Luciani A, Villella VR, Esposito S, Ferrari E, Bressani I, Casale A, Bruscia EM, Maiuri L, Raia V. Gavina M, et al. Among authors: esposito s. Pediatr Pulmonol. 2013 Aug;48(8):761-71. doi: 10.1002/ppul.22637. Epub 2012 Jul 23. Pediatr Pulmonol. 2013. PMID: 22825912
Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator.
Luciani A, Villella VR, Esposito S, Gavina M, Russo I, Silano M, Guido S, Pettoello-Mantovani M, Carnuccio R, Scholte B, De Matteis A, Maiuri MC, Raia V, Luini A, Kroemer G, Maiuri L. Luciani A, et al. Among authors: esposito s. Autophagy. 2012 Nov;8(11):1657-72. doi: 10.4161/auto.21483. Epub 2012 Aug 9. Autophagy. 2012. PMID: 22874563 Free PMC article.
Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localization in lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator.
Zhang PX, Murray TS, Villella VR, Ferrari E, Esposito S, D'Souza A, Raia V, Maiuri L, Krause DS, Egan ME, Bruscia EM. Zhang PX, et al. Among authors: esposito s. J Immunol. 2013 May 15;190(10):5196-206. doi: 10.4049/jimmunol.1201607. Epub 2013 Apr 19. J Immunol. 2013. PMID: 23606537 Free PMC article.
Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator.
Villella VR, Esposito S, Bruscia EM, Vicinanza M, Cenci S, Guido S, Pettoello-Mantovani M, Carnuccio R, De Matteis MA, Luini A, Maiuri MC, Raia V, Kroemer G, Maiuri L. Villella VR, et al. Among authors: esposito s. Cell Death Differ. 2013 Aug;20(8):1101-15. doi: 10.1038/cdd.2013.46. Epub 2013 May 17. Cell Death Differ. 2013. PMID: 23686137 Free PMC article.
1,905 results