Rautio J - Search Results

1

Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma.

Gynther M, Kääriäinen TM, Hakkarainen JJ, Jalkanen AJ, Petsalo A, Lehtonen M, Peura L, Kurkipuro J, Samaranayake H, Ylä-Herttuala S, Rautio J, Forsberg MM. Gynther M, et al. Among authors: rautio j. Drug Metab Dispos. 2015 Jan;43(1):140-6. doi: 10.1124/dmd.114.059840. Epub 2014 Oct 27. Drug Metab Dispos. 2015. PMID: 25349125

2

Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases.

Mannila A, Rautio J, Lehtonen M, Järvinen T, Savolainen J. Mannila A, et al. Among authors: rautio j. Eur J Pharm Sci. 2005 Jan;24(1):101-5. doi: 10.1016/j.ejps.2004.10.004. Eur J Pharm Sci. 2005. PMID: 15626583

3

Plasma and cerebrospinal fluid concentrations of indomethacin in children after intravenous administration.

Mannila A, Kumpulainen E, Lehtonen M, Heikkinen M, Laisalmi M, Salo T, Rautio J, Savolainen J, Kokki H. Mannila A, et al. Among authors: rautio j. J Clin Pharmacol. 2007 Jan;47(1):94-100. doi: 10.1177/0091270006295202. J Clin Pharmacol. 2007. PMID: 17192507 Clinical Trial.

4

Cerebrospinal fluid distribution of ibuprofen after intravenous administration in children.

Kokki H, Kumpulainen E, Lehtonen M, Laisalmi M, Heikkinen M, Savolainen J, Rautio J. Kokki H, et al. Among authors: rautio j. Pediatrics. 2007 Oct;120(4):e1002-8. doi: 10.1542/peds.2007-0064. Pediatrics. 2007. PMID: 17908721 Clinical Trial.

5

Large neutral amino acid transporter enables brain drug delivery via prodrugs.

Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T, Savolainen J, Järvinen T, Rautio J. Gynther M, et al. Among authors: rautio j. J Med Chem. 2008 Feb 28;51(4):932-6. doi: 10.1021/jm701175d. Epub 2008 Jan 25. J Med Chem. 2008. PMID: 18217702

6

How readily does ketorolac penetrate cerebrospinal fluid in children?

Kumpulainen E, Kokki H, Laisalmi M, Heikkinen M, Savolainen J, Rautio J, Lehtonen M. Kumpulainen E, et al. Among authors: rautio j. J Clin Pharmacol. 2008 Apr;48(4):495-501. doi: 10.1177/0091270007313389. Epub 2008 Feb 13. J Clin Pharmacol. 2008. PMID: 18272673 Clinical Trial.

7

Prodrug approaches for CNS delivery.

Rautio J, Laine K, Gynther M, Savolainen J. Rautio J, et al. AAPS J. 2008;10(1):92-102. doi: 10.1208/s12248-008-9009-8. Epub 2008 Feb 5. AAPS J. 2008. PMID: 18446509 Free PMC article. Review.

8

Diclofenac readily penetrates the cerebrospinal fluid in children.

Kokki H, Kumpulainen E, Laisalmi M, Savolainen J, Rautio J, Lehtonen M. Kokki H, et al. Among authors: rautio j. Br J Clin Pharmacol. 2008 Jun;65(6):879-84. doi: 10.1111/j.1365-2125.2008.03126.x. Br J Clin Pharmacol. 2008. PMID: 18477264 Free PMC article.

9

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.

Gynther M, Ropponen J, Laine K, Leppänen J, Haapakoski P, Peura L, Järvinen T, Rautio J. Gynther M, et al. Among authors: rautio j. J Med Chem. 2009 May 28;52(10):3348-53. doi: 10.1021/jm8015409. J Med Chem. 2009. PMID: 19402664

10

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor.

Rautio J, Leppänen J, Lehtonen M, Laine K, Koskinen M, Pystynen J, Savolainen J, Sairanen M. Rautio J, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2614-6. doi: 10.1016/j.bmcl.2010.02.057. Epub 2010 Feb 19. Bioorg Med Chem Lett. 2010. PMID: 20231095

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