Gynther M - Search Results

1

Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma.

Gynther M, Kääriäinen TM, Hakkarainen JJ, Jalkanen AJ, Petsalo A, Lehtonen M, Peura L, Kurkipuro J, Samaranayake H, Ylä-Herttuala S, Rautio J, Forsberg MM. Gynther M, et al. Drug Metab Dispos. 2015 Jan;43(1):140-6. doi: 10.1124/dmd.114.059840. Epub 2014 Oct 27. Drug Metab Dispos. 2015. PMID: 25349125

2

Large neutral amino acid transporter enables brain drug delivery via prodrugs.

Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T, Savolainen J, Järvinen T, Rautio J. Gynther M, et al. J Med Chem. 2008 Feb 28;51(4):932-6. doi: 10.1021/jm701175d. Epub 2008 Jan 25. J Med Chem. 2008. PMID: 18217702

3

Prodrug approaches for CNS delivery.

Rautio J, Laine K, Gynther M, Savolainen J. Rautio J, et al. Among authors: gynther m. AAPS J. 2008;10(1):92-102. doi: 10.1208/s12248-008-9009-8. Epub 2008 Feb 5. AAPS J. 2008. PMID: 18446509 Free PMC article. Review.

4

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.

Gynther M, Ropponen J, Laine K, Leppänen J, Haapakoski P, Peura L, Järvinen T, Rautio J. Gynther M, et al. J Med Chem. 2009 May 28;52(10):3348-53. doi: 10.1021/jm8015409. J Med Chem. 2009. PMID: 19402664

5

Brain uptake of ketoprofen-lysine prodrug in rats.

Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J, Rautio J. Gynther M, et al. Int J Pharm. 2010 Oct 31;399(1-2):121-8. doi: 10.1016/j.ijpharm.2010.08.019. Epub 2010 Aug 19. Int J Pharm. 2010. PMID: 20727958

6

Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.

Peura L, Malmioja K, Laine K, Leppänen J, Gynther M, Isotalo A, Rautio J. Peura L, et al. Among authors: gynther m. Mol Pharm. 2011 Oct 3;8(5):1857-66. doi: 10.1021/mp2001878. Epub 2011 Aug 9. Mol Pharm. 2011. PMID: 21770378

7

LAT1-mediated prodrug uptake: a way to breach the blood-brain barrier?

Rautio J, Gynther M, Laine K. Rautio J, et al. Among authors: gynther m. Ther Deliv. 2013 Mar;4(3):281-4. doi: 10.4155/tde.12.165. Ther Deliv. 2013. PMID: 23442072 Free article. No abstract available.

8

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.

Peura L, Malmioja K, Huttunen K, Leppänen J, Hämäläinen M, Forsberg MM, Gynther M, Rautio J, Laine K. Peura L, et al. Among authors: gynther m. Pharm Res. 2013 Oct;30(10):2523-37. doi: 10.1007/s11095-012-0966-3. Pharm Res. 2013. PMID: 24137801

9

Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).

Ylikangas H, Malmioja K, Peura L, Gynther M, Nwachukwu EO, Leppänen J, Laine K, Rautio J, Lahtela-Kakkonen M, Huttunen KM, Poso A. Ylikangas H, et al. Among authors: gynther m. ChemMedChem. 2014 Dec;9(12):2699-707. doi: 10.1002/cmdc.201402281. Epub 2014 Sep 9. ChemMedChem. 2014. PMID: 25205473

10

Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1).

Rautio J, Kärkkäinen J, Huttunen KM, Gynther M. Rautio J, et al. Among authors: gynther m. Eur J Pharm Sci. 2015 Jan 23;66:36-40. doi: 10.1016/j.ejps.2014.09.025. Epub 2014 Oct 8. Eur J Pharm Sci. 2015. PMID: 25305508

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