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In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.
Hübner MP, Koschel M, Struever D, Nikolov V, Frohberger SJ, Ehrens A, Fendler M, Johannes I, von Geldern TW, Marsh K, Turner JD, Taylor MJ, Ward SA, Pfarr K, Kempf DJ, Hoerauf A. Hübner MP, et al. Among authors: fendler m. PLoS Negl Trop Dis. 2019 Aug 5;13(8):e0007636. doi: 10.1371/journal.pntd.0007636. eCollection 2019 Aug. PLoS Negl Trop Dis. 2019. PMID: 31381563 Free PMC article.
Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models.
Hübner MP, Gunderson E, Vogel I, Bulman CA, Lim KC, Koschel M, Ehrens A, Frohberger SJ, Fendler M, Tricoche N, Voronin D, Steven A, Chi V, Bakowski MA, Woods AK, Petrassi HM, McNamara CW, Beerntsen B, Chappell L, Sullivan W, Taylor MJ, Turner JD, Hoerauf A, Lustigman S, Sakanari JA. Hübner MP, et al. Among authors: fendler m. Int J Parasitol Drugs Drug Resist. 2020 Apr;12:18-27. doi: 10.1016/j.ijpddr.2019.12.001. Epub 2019 Dec 10. Int J Parasitol Drugs Drug Resist. 2020. PMID: 31869759 Free PMC article.
In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.
Ehrens A, Lunde CS, Jacobs RT, Struever D, Koschel M, Frohberger SJ, Lenz F, Fendler M, Turner JD, Ward SA, Taylor MJ, Freund YR, Stefanakis R, Easom E, Li X, Plattner JJ, Hoerauf A, Hübner MP. Ehrens A, et al. Among authors: fendler m. PLoS Negl Trop Dis. 2020 Jan 27;14(1):e0007957. doi: 10.1371/journal.pntd.0007957. eCollection 2020 Jan. PLoS Negl Trop Dis. 2020. PMID: 31986143 Free PMC article.
Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.
Hübner MP, Martin C, Specht S, Koschel M, Dubben B, Frohberger SJ, Ehrens A, Fendler M, Struever D, Mitre E, Vallarino-Lhermitte N, Gokool S, Lustigman S, Schneider M, Townson S, Hoerauf A, Scandale I. Hübner MP, et al. Among authors: fendler m. PLoS Negl Trop Dis. 2020 Jul 6;14(7):e0008427. doi: 10.1371/journal.pntd.0008427. eCollection 2020 Jul. PLoS Negl Trop Dis. 2020. PMID: 32628671 Free PMC article.
The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system.
Risch F, Scheunemann JF, Reichwald JJ, Lenz B, Ehrens A, Gal J, Fercoq F, Koschel M, Fendler M, Hoerauf A, Martin C, Hübner MP. Risch F, et al. Among authors: fendler m. Front Microbiol. 2023 Jun 27;14:1213143. doi: 10.3389/fmicb.2023.1213143. eCollection 2023. Front Microbiol. 2023. PMID: 37440891 Free PMC article.
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