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Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors.
Dražić T, Molčanov K, Sachdev V, Malnar M, Hećimović S, Patankar JV, Obrowsky S, Levak-Frank S, Habuš I, Kratky D. Dražić T, et al. Among authors: obrowsky s. Eur J Med Chem. 2014 Nov 24;87:722-34. doi: 10.1016/j.ejmech.2014.10.014. Epub 2014 Oct 7. Eur J Med Chem. 2014. PMID: 25305716 Free PMC article.
Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis.
Patankar JV, Obrowsky S, Doddapattar P, Hoefler G, Battle M, Levak-Frank S, Kratky D. Patankar JV, et al. Among authors: obrowsky s. J Hepatol. 2012 Nov;57(5):1061-8. doi: 10.1016/j.jhep.2012.06.028. Epub 2012 Jun 28. J Hepatol. 2012. PMID: 22750465 Free PMC article.
Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.
Sachdev V, Leopold C, Bauer R, Patankar JV, Iqbal J, Obrowsky S, Boverhof R, Doktorova M, Scheicher B, Goeritzer M, Kolb D, Turnbull AV, Zimmer A, Hoefler G, Hussain MM, Groen AK, Kratky D. Sachdev V, et al. Among authors: obrowsky s. Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):1132-1141. doi: 10.1016/j.bbalip.2016.06.014. Epub 2016 Jun 23. Biochim Biophys Acta. 2016. PMID: 27344248 Free PMC article.
Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.
Patankar JV, Chandak PG, Obrowsky S, Pfeifer T, Diwoky C, Uellen A, Sattler W, Stollberger R, Hoefler G, Heinemann A, Battle M, Duncan S, Kratky D, Levak-Frank S. Patankar JV, et al. Among authors: obrowsky s. Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E478-88. doi: 10.1152/ajpendo.00457.2010. Epub 2010 Dec 21. Am J Physiol Endocrinol Metab. 2011. PMID: 21177287 Free PMC article.
Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice.
Chandak PG, Obrowsky S, Radovic B, Doddapattar P, Aflaki E, Kratzer A, Doshi LS, Povoden S, Ahammer H, Hoefler G, Levak-Frank S, Kratky D. Chandak PG, et al. Among authors: obrowsky s. Biochim Biophys Acta. 2011 Dec;1811(12):1011-20. doi: 10.1016/j.bbalip.2011.08.010. Epub 2011 Sep 1. Biochim Biophys Acta. 2011. PMID: 21924378 Free PMC article.
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Doddapattar P, Radović B, Patankar JV, Obrowsky S, Jandl K, Nusshold C, Kolb D, Vujić N, Doshi L, Chandak PG, Goeritzer M, Ahammer H, Hoefler G, Sattler W, Kratky D. Doddapattar P, et al. Among authors: obrowsky s. Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3. Mol Nutr Food Res. 2013. PMID: 23650230 Free PMC article.
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