HIF-1α stabilization reduces retinal degeneration in a mouse model of retinitis pigmentosa.
Olivares-González L, Martínez-Fernández de la Cámara C, Hervás D, Millán JM, Rodrigo R.
Olivares-González L, et al. Among authors: hervas d.
FASEB J. 2018 May;32(5):2438-2451. doi: 10.1096/fj.201700985R. Epub 2018 Jan 8.
FASEB J. 2018.
PMID: 29295858
A generalized down-regulation of HIF-1alpha and its downstream targets was detected in parallel with reactive gliosis, suggesting high oxygen levels during retinal degeneration. At postnatal d 18, DMOG treatment reduced photoreceptor cell death and glial activation. ...-Ol …
A generalized down-regulation of HIF-1alpha and its downstream targets was detected in parallel with reactive gliosis, suggesting high oxyge …