Markert M - Search Results

1

Potent cholesteryl ester transfer protein inhibitors of reduced lipophilicity: 1,1'-spiro-substituted hexahydrofuroquinoline derivatives.

Trieselmann T, Wagner H, Fuchs K, Hamprecht D, Berta D, Cremonesi P, Streicher R, Luippold G, Volz A, Markert M, Nar H. Trieselmann T, et al. Among authors: markert m. J Med Chem. 2014 Nov 13;57(21):8766-76. doi: 10.1021/jm500431d. Epub 2014 Oct 27. J Med Chem. 2014. PMID: 25265559

2

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908.

Oost T, Heckel A, Kley JT, Lehmann T, Müller S, Roth GJ, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Maier GM, Markert M, Thomas L, Stenkamp D. Oost T, et al. Among authors: markert m. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3275-80. doi: 10.1016/j.bmcl.2015.05.065. Epub 2015 May 29. Bioorg Med Chem Lett. 2015. PMID: 26105194

3

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414.

Müller SG, Heckel A, Kley JT, Lehmann T, Lustenberger P, Oost T, Roth GJ, Rudolf K, Arndt K, Lenter M, Lotz RR, Maier GM, Markert M, Schindler M, Stenkamp D. Müller SG, et al. Among authors: markert m. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3264-9. doi: 10.1016/j.bmcl.2015.05.077. Epub 2015 Jun 6. Bioorg Med Chem Lett. 2015. PMID: 26112443

4

Evaluation of a method to correct the contractility index LVdP/dt(max) for changes in heart rate.

Markert M, Trautmann T, Groß M, Ege A, Mayer K, Guth B. Markert M, et al. J Pharmacol Toxicol Methods. 2012 Sep;66(2):98-105. doi: 10.1016/j.vascn.2012.04.005. Epub 2012 Apr 23. J Pharmacol Toxicol Methods. 2012. PMID: 22554385

5

Validation of the normal, freely moving Göttingen minipig for pharmacological safety testing.

Markert M, Stubhan M, Mayer K, Trautmann T, Klumpp A, Schuler-Metz A, Schumacher K, Guth B. Markert M, et al. J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):79-87. doi: 10.1016/j.vascn.2008.12.004. Epub 2009 May 8. J Pharmacol Toxicol Methods. 2009. PMID: 19427912

6

Cardiovascular safety pharmacology studies in dogs enabled for a poorly soluble molecule using spray-dried dispersion: Impact on lead selection.

Tseng YC, Linehan B, Ng KJ, Smith DM, Markert M, Patel M, Guth B, Fryer RM. Tseng YC, et al. Among authors: markert m. Int J Pharm. 2016 Oct 15;512(1):137-146. doi: 10.1016/j.ijpharm.2016.08.028. Epub 2016 Aug 16. Int J Pharm. 2016. PMID: 27543349

7

The value added by measuring myocardial contractility 'in vivo' in safety pharmacological profiling of drug candidates.

Markert M, Klumpp A, Trautmann T, Mayer K, Stubhan M, Guth B. Markert M, et al. J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):203-11. doi: 10.1016/j.vascn.2007.03.004. Epub 2007 May 24. J Pharmacol Toxicol Methods. 2007. PMID: 17583538

8

A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud data transmission.

Markert M, Trautmann T, Krause F, Cioaga M, Mouriot S, Wetzel M, Guth BD. Markert M, et al. J Pharmacol Toxicol Methods. 2018 Sep-Oct;93:90-97. doi: 10.1016/j.vascn.2018.03.006. Epub 2018 Mar 26. J Pharmacol Toxicol Methods. 2018. PMID: 29597013

9

Continuous assessment of multiple vital physiological functions in conscious freely moving rats using telemetry and a plethysmography system.

Schierok H, Markert M, Pairet M, Guth B. Schierok H, et al. Among authors: markert m. J Pharmacol Toxicol Methods. 2000 May-Jun;43(3):211-7. doi: 10.1016/s1056-8719(00)00101-5. J Pharmacol Toxicol Methods. 2000. PMID: 11257486

10

Developing a strategy for the nonclinical assessment of proarrhythmic risk of pharmaceuticals due to prolonged ventricular repolarization.

Guth BD, Germeyer S, Kolb W, Markert M. Guth BD, et al. Among authors: markert m. J Pharmacol Toxicol Methods. 2004 May-Jun;49(3):159-69. doi: 10.1016/j.vascn.2004.02.006. J Pharmacol Toxicol Methods. 2004. PMID: 15172012 Review.

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