Reddy GS - Search Results

1

Synthesis and metabolic studies of 1α,2α,25-, 1α,4α,25- and 1α,4β,25-trihydroxyvitamin D3.

Takano M, Sawada D, Yasuda K, Nishikawa M, Takeuchi A, Takagi K, Horie K, Reddy GS, Chen TC, Sakaki T, Kittaka A. Takano M, et al. Among authors: reddy gs. J Steroid Biochem Mol Biol. 2015 Apr;148:34-7. doi: 10.1016/j.jsbmb.2014.09.021. Epub 2014 Sep 26. J Steroid Biochem Mol Biol. 2015. PMID: 25263656 Review.

2

Synthesis and biological activities of 1α,4α,25- and 1α,4β,25-trihydroxyvitamin D(3) and their metabolism by human CYP24A1 and UDP-glucuronosyltransferase.

Sawada D, Tsukuda Y, Yasuda K, Sakaki T, Saito H, Takagi K, Takenouchi K, Chen TC, Reddy GS, Kittaka A. Sawada D, et al. Among authors: reddy gs. Chem Pharm Bull (Tokyo). 2012;60(10):1343-6. doi: 10.1248/cpb.c12-00526. Chem Pharm Bull (Tokyo). 2012. PMID: 23036975 Free article.

3

Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1.

Rhieu SY, Annalora AJ, LaPorta E, Welsh J, Itoh T, Yamamoto K, Sakaki T, Chen TC, Uskokovic MR, Reddy GS. Rhieu SY, et al. Among authors: reddy gs. J Cell Biochem. 2014 Aug;115(8):1392-402. doi: 10.1002/jcb.24789. J Cell Biochem. 2014. PMID: 24535953

4

Measurement and characterization of C-3 epimerization activity toward vitamin D3.

Kamao M, Hatakeyama S, Sakaki T, Sawada N, Inouye K, Kubodera N, Reddy GS, Okano T. Kamao M, et al. Among authors: reddy gs. Arch Biochem Biophys. 2005 Apr 1;436(1):196-205. doi: 10.1016/j.abb.2005.01.017. Arch Biochem Biophys. 2005. PMID: 15752725

5

C-3 epimerization of vitamin D3 metabolites and further metabolism of C-3 epimers: 25-hydroxyvitamin D3 is metabolized to 3-epi-25-hydroxyvitamin D3 and subsequently metabolized through C-1alpha or C-24 hydroxylation.

Kamao M, Tatematsu S, Hatakeyama S, Sakaki T, Sawada N, Inouye K, Ozono K, Kubodera N, Reddy GS, Okano T. Kamao M, et al. Among authors: reddy gs. J Biol Chem. 2004 Apr 16;279(16):15897-907. doi: 10.1074/jbc.M311473200. Epub 2004 Feb 2. J Biol Chem. 2004. PMID: 14757768 Free article.

6

Nuclear factor of activated T cells (NFAT) as a molecular target for 1alpha,25-dihydroxyvitamin D3-mediated effects.

Takeuchi A, Reddy GS, Kobayashi T, Okano T, Park J, Sharma S. Takeuchi A, et al. Among authors: reddy gs. J Immunol. 1998 Jan 1;160(1):209-18. J Immunol. 1998. PMID: 9551973

7

Metabolic stability of 3-epi-1α,25-dihydroxyvitamin D3 over 1 α 25-dihydroxyvitamin D3: metabolism and molecular docking studies using rat CYP24A1.

Rhieu SY, Annalora AJ, Wang G, Flarakos CC, Gathungu RM, Vouros P, Sigüeiro R, Mouriño A, Schuster I, Palmore GT, Reddy GS. Rhieu SY, et al. Among authors: reddy gs. J Cell Biochem. 2013 Oct;114(10):2293-305. doi: 10.1002/jcb.24576. J Cell Biochem. 2013. PMID: 23606409

8

Removal of C-ring from the CD-ring skeleton of 1alpha,25-dihydroxyvitamin D3 does not alter its target tissue metabolism significantly.

Reddy GS, Robinson M, Wang G, Palmore GT, Gennaro L, Vouros P, De Clercq P, Vandewalle M, Young W, Ling S, Verstuyf A, Bouillon R. Reddy GS, et al. Arch Biochem Biophys. 2007 Apr 15;460(2):254-61. doi: 10.1016/j.abb.2006.11.012. Epub 2006 Nov 21. Arch Biochem Biophys. 2007. PMID: 17196157

9

Enhanced biological activity of 1alpha,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1alpha,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity.

Siu-Caldera ML, Sekimoto H, Peleg S, Nguyen C, Kissmeyer AM, Binderup L, Weiskopf A, Vouros P, Uskoković MR, Reddy GS. Siu-Caldera ML, et al. Among authors: reddy gs. J Steroid Biochem Mol Biol. 1999 Dec 15;71(3-4):111-21. doi: 10.1016/s0960-0760(99)00130-2. J Steroid Biochem Mol Biol. 1999. PMID: 10659699

10

Highly active analogs of 1alpha,25-dihydroxyvitamin D(3) that resist metabolism through C-24 oxidation and C-3 epimerization pathways.

Uskokovic MR, Norman AW, Manchand PS, Studzinski GP, Campbell MJ, Koeffler HP, Takeuchi A, Siu-Caldera ML, Rao DS, Reddy GS. Uskokovic MR, et al. Among authors: reddy gs. Steroids. 2001 Mar-May;66(3-5):463-71. doi: 10.1016/s0039-128x(00)00226-9. Steroids. 2001. PMID: 11179755 Review.

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