Myant K - Search Results

1

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.

Peter S, Bultinck J, Myant K, Jaenicke LA, Walz S, Müller J, Gmachl M, Treu M, Boehmelt G, Ade CP, Schmitz W, Wiegering A, Otto C, Popov N, Sansom O, Kraut N, Eilers M. Peter S, et al. Among authors: myant k. EMBO Mol Med. 2014 Dec;6(12):1525-41. doi: 10.15252/emmm.201403927. EMBO Mol Med. 2014. PMID: 25253726 Free PMC article.

2

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ. Ashton GH, et al. Among authors: myant k. Dev Cell. 2010 Aug 17;19(2):259-69. doi: 10.1016/j.devcel.2010.07.015. Dev Cell. 2010. PMID: 20708588 Free PMC article.

3

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.

Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ. Cole AM, et al. Among authors: myant k. Cancer Res. 2010 Oct 15;70(20):8149-58. doi: 10.1158/0008-5472.CAN-10-0315. Epub 2010 Aug 24. Cancer Res. 2010. PMID: 20736363 Free PMC article.

4

A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis.

Morton JP, Myant KB, Sansom OJ. Morton JP, et al. Cell Cycle. 2011 Jan 15;10(2):173-5. doi: 10.4161/cc.10.2.14350. Epub 2011 Jan 15. Cell Cycle. 2011. PMID: 21228625 No abstract available.

5

Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex.

Myant K, Sansom O. Myant K, et al. Cell Div. 2011 Feb 2;6(1):3. doi: 10.1186/1747-1028-6-3. Cell Div. 2011. PMID: 21288356 Free PMC article.

6

More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer.

Myant K, Sansom OJ. Myant K, et al. Mol Cell. 2011 Feb 18;41(4):369-70. doi: 10.1016/j.molcel.2011.01.028. Mol Cell. 2011. PMID: 21329875 Free article.

7

Wnt/Myc interactions in intestinal cancer: partners in crime.

Myant K, Sansom OJ. Myant K, et al. Exp Cell Res. 2011 Nov 15;317(19):2725-31. doi: 10.1016/j.yexcr.2011.08.001. Epub 2011 Aug 7. Exp Cell Res. 2011. PMID: 21851818 Review.

8

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.

Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H. Muñoz J, et al. Among authors: myant k. EMBO J. 2012 Jun 12;31(14):3079-91. doi: 10.1038/emboj.2012.166. EMBO J. 2012. PMID: 22692129 Free PMC article.

9

Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut.

Cordero JB, Stefanatos RK, Myant K, Vidal M, Sansom OJ. Cordero JB, et al. Among authors: myant k. Development. 2012 Dec;139(24):4524-35. doi: 10.1242/dev.078261. Development. 2012. PMID: 23172913

10

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.

Myant KB, Cammareri P, McGhee EJ, Ridgway RA, Huels DJ, Cordero JB, Schwitalla S, Kalna G, Ogg EL, Athineos D, Timpson P, Vidal M, Murray GI, Greten FR, Anderson KI, Sansom OJ. Myant KB, et al. Cell Stem Cell. 2013 Jun 6;12(6):761-73. doi: 10.1016/j.stem.2013.04.006. Epub 2013 May 9. Cell Stem Cell. 2013. PMID: 23665120 Free PMC article.

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