Chesler L - Search Results

1

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma.

Moore NF, Azarova AM, Bhatnagar N, Ross KN, Drake LE, Frumm S, Liu QS, Christie AL, Sanda T, Chesler L, Kung AL, Gray NS, Stegmaier K, George RE. Moore NF, et al. Among authors: chesler l. Oncotarget. 2014 Sep 30;5(18):8737-49. doi: 10.18632/oncotarget.2372. Oncotarget. 2014. PMID: 25228590 Free PMC article.

2

The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo.

Faisal A, Vaughan L, Bavetsias V, Sun C, Atrash B, Avery S, Jamin Y, Robinson SP, Workman P, Blagg J, Raynaud FI, Eccles SA, Chesler L, Linardopoulos S. Faisal A, et al. Among authors: chesler l. Mol Cancer Ther. 2011 Nov;10(11):2115-23. doi: 10.1158/1535-7163.MCT-11-0333. Epub 2011 Sep 1. Mol Cancer Ther. 2011. PMID: 21885865 Free PMC article.

3

The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma.

Berry T, Luther W, Bhatnagar N, Jamin Y, Poon E, Sanda T, Pei D, Sharma B, Vetharoy WR, Hallsworth A, Ahmad Z, Barker K, Moreau L, Webber H, Wang W, Liu Q, Perez-Atayde A, Rodig S, Cheung NK, Raynaud F, Hallberg B, Robinson SP, Gray NS, Pearson AD, Eccles SA, Chesler L, George RE. Berry T, et al. Among authors: chesler l. Cancer Cell. 2012 Jul 10;22(1):117-30. doi: 10.1016/j.ccr.2012.06.001. Cancer Cell. 2012. PMID: 22789543 Free PMC article.

4

New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK.

Barone G, Anderson J, Pearson AD, Petrie K, Chesler L. Barone G, et al. Among authors: chesler l. Clin Cancer Res. 2013 Nov 1;19(21):5814-21. doi: 10.1158/1078-0432.CCR-13-0680. Epub 2013 Aug 21. Clin Cancer Res. 2013. PMID: 23965898 Free PMC article. Review.

5

Intrinsic susceptibility MRI identifies tumors with ALKF1174L mutation in genetically-engineered murine models of high-risk neuroblastoma.

Jamin Y, Glass L, Hallsworth A, George R, Koh DM, Pearson AD, Chesler L, Robinson SP. Jamin Y, et al. Among authors: chesler l. PLoS One. 2014 Mar 25;9(3):e92886. doi: 10.1371/journal.pone.0092886. eCollection 2014. PLoS One. 2014. PMID: 24667968 Free PMC article.

6

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma.

Umapathy G, El Wakil A, Witek B, Chesler L, Danielson L, Deng X, Gray NS, Johansson M, Kvarnbrink S, Ruuth K, Schönherr C, Palmer RH, Hallberg B. Umapathy G, et al. Among authors: chesler l. Sci Signal. 2014 Oct 28;7(349):ra102. doi: 10.1126/scisignal.2005470. Sci Signal. 2014. PMID: 25351247

7

Tackling Crizotinib Resistance: The Pathway from Drug Discovery to the Pediatric Clinic.

Tucker ER, Danielson LS, Innocenti P, Chesler L. Tucker ER, et al. Among authors: chesler l. Cancer Res. 2015 Jul 15;75(14):2770-4. doi: 10.1158/0008-5472.CAN-14-3817. Epub 2015 Jun 29. Cancer Res. 2015. PMID: 26122839 Free PMC article. Review.

8

Novel pharmacodynamic biomarkers for MYCN protein and PI3K/AKT/mTOR pathway signaling in children with neuroblastoma.

Smith JR, Moreno L, Heaton SP, Chesler L, Pearson AD, Garrett MD. Smith JR, et al. Among authors: chesler l. Mol Oncol. 2016 Apr;10(4):538-52. doi: 10.1016/j.molonc.2015.11.005. Epub 2015 Nov 19. Mol Oncol. 2016. PMID: 26686971 Free PMC article. Clinical Trial.

9

Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors.

Vaughan L, Clarke PA, Barker K, Chanthery Y, Gustafson CW, Tucker E, Renshaw J, Raynaud F, Li X, Burke R, Jamin Y, Robinson SP, Pearson A, Maira M, Weiss WA, Workman P, Chesler L. Vaughan L, et al. Among authors: chesler l. Oncotarget. 2016 Sep 6;7(36):57525-57544. doi: 10.18632/oncotarget.10544. Oncotarget. 2016. PMID: 27438153 Free PMC article.

10

The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN.

Guan J, Tucker ER, Wan H, Chand D, Danielson LS, Ruuth K, El Wakil A, Witek B, Jamin Y, Umapathy G, Robinson SP, Johnson TW, Smeal T, Martinsson T, Chesler L, Palmer RH, Hallberg B. Guan J, et al. Among authors: chesler l. Dis Model Mech. 2016 Sep 1;9(9):941-52. doi: 10.1242/dmm.024448. Epub 2016 Jul 7. Dis Model Mech. 2016. PMID: 27483357 Free PMC article.

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