Ross D - Search Results

1

Discovery and characterization of small molecules that target the GTPase Ral.

Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D. Yan C, et al. Among authors: ross d. Nature. 2014 Nov 20;515(7527):443-7. doi: 10.1038/nature13713. Epub 2014 Sep 14. Nature. 2014. PMID: 25219851 Free PMC article.

2

Synthesis of novel Ral inhibitors: An in vitro and in vivo study.

Yan C, Theodorescu D, Miller B, Kumar A, Kumar V, Ross D, Wempe MF. Yan C, et al. Among authors: ross d. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5815-5818. doi: 10.1016/j.bmcl.2016.10.021. Epub 2016 Oct 12. Bioorg Med Chem Lett. 2016. PMID: 27825764 Free PMC article.

3

Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target.

Yan C, Shieh B, Reigan P, Zhang Z, Colucci MA, Chilloux A, Newsome JJ, Siegel D, Chan D, Moody CJ, Ross D. Yan C, et al. Among authors: ross d. Mol Pharmacol. 2009 Jul;76(1):163-72. doi: 10.1124/mol.109.055855. Epub 2009 Apr 13. Mol Pharmacol. 2009. PMID: 19364812 Free PMC article.

4

Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling.

Yan C, Siegel D, Newsome J, Chilloux A, Moody CJ, Ross D. Yan C, et al. Among authors: ross d. Mol Pharmacol. 2012 Mar;81(3):401-10. doi: 10.1124/mol.111.076091. Epub 2011 Dec 6. Mol Pharmacol. 2012. PMID: 22147753 Free PMC article.

5

NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones.

Siegel D, Yan C, Ross D. Siegel D, et al. Among authors: ross d. Biochem Pharmacol. 2012 Apr 15;83(8):1033-40. doi: 10.1016/j.bcp.2011.12.017. Epub 2011 Dec 24. Biochem Pharmacol. 2012. PMID: 22209713 Free PMC article. Review.

6

Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells.

Siegel D, Shieh B, Yan C, Kepa JK, Ross D. Siegel D, et al. Among authors: ross d. J Pharmacol Exp Ther. 2011 Mar;336(3):874-80. doi: 10.1124/jpet.110.176438. Epub 2010 Dec 14. J Pharmacol Exp Ther. 2011. PMID: 21156818 Free PMC article.

7

Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1).

Yan C, Kepa JK, Siegel D, Stratford IJ, Ross D. Yan C, et al. Among authors: ross d. Mol Pharmacol. 2008 Dec;74(6):1657-65. doi: 10.1124/mol.108.050401. Epub 2008 Sep 15. Mol Pharmacol. 2008. PMID: 18794327 Free PMC article.

8

Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems.

Yan C, Dufour M, Siegel D, Reigan P, Gomez J, Shieh B, Moody CJ, Ross D. Yan C, et al. Among authors: ross d. Biochemistry. 2011 Aug 9;50(31):6678-88. doi: 10.1021/bi2002967. Epub 2011 Jul 19. Biochemistry. 2011. PMID: 21718050 Free PMC article.

9

Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition.

Dufour M, Yan C, Siegel D, Colucci MA, Jenner M, Oldham NJ, Gomez J, Reigan P, Li Y, De Matteis CI, Ross D, Moody CJ. Dufour M, et al. Among authors: ross d. Chembiochem. 2011 May 16;12(8):1203-8. doi: 10.1002/cbic.201100085. Epub 2011 Apr 19. Chembiochem. 2011. PMID: 21506232 Free PMC article.

10

Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells.

Inman M, Visconti A, Yan C, Siegel D, Ross D, Moody CJ. Inman M, et al. Among authors: ross d. Org Biomol Chem. 2014 Jul 21;12(27):4848-61. doi: 10.1039/c4ob00711e. Org Biomol Chem. 2014. PMID: 24848343 Free PMC article.

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