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Human papillomavirus type 1 E1^E4 protein is a potent inhibitor of the serine-arginine (SR) protein kinase SRPK1 and inhibits phosphorylation of host SR proteins and of the viral transcription and replication regulator E2.
Prescott EL, Brimacombe CL, Hartley M, Bell I, Graham S, Roberts S. Prescott EL, et al. Among authors: brimacombe cl. J Virol. 2014 Nov;88(21):12599-611. doi: 10.1128/JVI.02029-14. Epub 2014 Aug 20. J Virol. 2014. PMID: 25142587 Free PMC article.
Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity.
Farquhar MJ, Harris HJ, Diskar M, Jones S, Mee CJ, Nielsen SU, Brimacombe CL, Molina S, Toms GL, Maurel P, Howl J, Herberg FW, van Ijzendoorn SC, Balfe P, McKeating JA. Farquhar MJ, et al. Among authors: brimacombe cl. J Virol. 2008 Sep;82(17):8797-811. doi: 10.1128/JVI.00592-08. Epub 2008 Jun 25. J Virol. 2008. PMID: 18579596 Free PMC article.
Hepatitis C virus induces CD81 and claudin-1 endocytosis.
Farquhar MJ, Hu K, Harris HJ, Davis C, Brimacombe CL, Fletcher SJ, Baumert TF, Rappoport JZ, Balfe P, McKeating JA. Farquhar MJ, et al. Among authors: brimacombe cl. J Virol. 2012 Apr;86(8):4305-16. doi: 10.1128/JVI.06996-11. Epub 2012 Feb 8. J Virol. 2012. PMID: 22318146 Free PMC article.
Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission.
Brimacombe CL, Grove J, Meredith LW, Hu K, Syder AJ, Flores MV, Timpe JM, Krieger SE, Baumert TF, Tellinghuisen TL, Wong-Staal F, Balfe P, McKeating JA. Brimacombe CL, et al. J Virol. 2011 Jan;85(1):596-605. doi: 10.1128/JVI.01592-10. Epub 2010 Oct 20. J Virol. 2011. PMID: 20962076 Free PMC article.
A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration.
Wilson GK, Brimacombe CL, Rowe IA, Reynolds GM, Fletcher NF, Stamataki Z, Bhogal RH, Simões ML, Ashcroft M, Afford SC, Mitry RR, Dhawan A, Mee CJ, Hübscher SG, Balfe P, McKeating JA. Wilson GK, et al. Among authors: brimacombe cl. J Hepatol. 2012 Apr;56(4):803-9. doi: 10.1016/j.jhep.2011.11.018. Epub 2011 Dec 16. J Hepatol. 2012. PMID: 22178269 Free PMC article.
Multiple effects of silymarin on the hepatitis C virus lifecycle.
Wagoner J, Negash A, Kane OJ, Martinez LE, Nahmias Y, Bourne N, Owen DM, Grove J, Brimacombe C, McKeating JA, Pécheur EI, Graf TN, Oberlies NH, Lohmann V, Cao F, Tavis JE, Polyak SJ. Wagoner J, et al. Hepatology. 2010 Jun;51(6):1912-21. doi: 10.1002/hep.23587. Hepatology. 2010. PMID: 20512985 Free PMC article.