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Apollon/Bruce is upregulated by Humanin.
Hashimoto Y, Takeshita Y, Naito M, Uchino H, Matsuoka M. Hashimoto Y, et al. Mol Cell Biochem. 2014 Dec;397(1-2):147-55. doi: 10.1007/s11010-014-2182-4. Epub 2014 Aug 20. Mol Cell Biochem. 2014. PMID: 25138702
Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization.
Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S, Nishimoto I. Terashita K, et al. Among authors: hashimoto y. J Neurochem. 2003 Jun;85(6):1521-38. doi: 10.1046/j.1471-4159.2003.01797.x. J Neurochem. 2003. PMID: 12787071 Free article.
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.
Hashimoto Y, Niikura T, Chiba T, Tsukamoto E, Kadowaki H, Nishitoh H, Yamagishi Y, Ishizaka M, Yamada M, Nawa M, Terashita K, Aiso S, Ichijo H, Nishimoto I. Hashimoto Y, et al. J Pharmacol Exp Ther. 2003 Sep;306(3):889-902. doi: 10.1124/jpet.103.051383. Epub 2003 Jun 26. J Pharmacol Exp Ther. 2003. PMID: 12829723
Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.
Hashimoto Y, Terashita K, Niikura T, Yamagishi Y, Ishizaka M, Kanekura K, Chiba T, Yamada M, Kita Y, Aiso S, Matsuoka M, Nishimoto I. Hashimoto Y, et al. Eur J Neurosci. 2004 May;19(9):2356-64. doi: 10.1111/j.0953-816X.2004.03298.x. Eur J Neurosci. 2004. PMID: 15128389
We have previously shown that P3A, S7A, C8A, L9A, L12A, T13A, S14A and P19A mutations nullify the neuroprotective function of HN [Yamagishi, Y., Hashimoto, Y., Niikura, T. & Nishimoto, I. (2003) Peptides, 24, 585-595]. ...
We have previously shown that P3A, S7A, C8A, L9A, L12A, T13A, S14A and P19A mutations nullify the neuroprotective function of HN [Yamagishi, …
5,236 results