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Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Westbrook RL, Bridges E, Roberts J, Escribano-Gonzalez C, Eales KL, Vettore LA, Walker PD, Vera-Siguenza E, Rana H, Cuozzo F, Eskla KL, Vellama H, Shaaban A, Nixon C, Luuk H, Lavery GG, Hodson DJ, Harris AL, Tennant DA. Westbrook RL, et al. Among authors: eales kl. Cell Rep. 2022 Feb 1;38(5):110320. doi: 10.1016/j.celrep.2022.110320. Cell Rep. 2022. PMID: 35108535 Free PMC article.
Genomic and in Situ Analyses Reveal the Micropruina spp. as Abundant Fermentative Glycogen Accumulating Organisms in Enhanced Biological Phosphorus Removal Systems.
McIlroy SJ, Onetto CA, McIlroy B, Herbst FA, Dueholm MS, Kirkegaard RH, Fernando E, Karst SM, Nierychlo M, Kristensen JM, Eales KL, Grbin PR, Wimmer R, Nielsen PH. McIlroy SJ, et al. Among authors: eales kl. Front Microbiol. 2018 May 23;9:1004. doi: 10.3389/fmicb.2018.01004. eCollection 2018. Front Microbiol. 2018. PMID: 29875741 Free PMC article.
Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA. Hollinshead KER, et al. Among authors: eales kl. Cell Rep. 2018 Mar 20;22(12):3107-3114. doi: 10.1016/j.celrep.2018.02.084. Cell Rep. 2018. PMID: 29562167 Free PMC article.
15 results