Phuan PW - Search Results

1

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. Veit G, et al. Among authors: phuan pw. Sci Transl Med. 2014 Jul 23;6(246):246ra97. doi: 10.1126/scitranslmed.3008889. Sci Transl Med. 2014. PMID: 25101887 Free PMC article.

2

Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.

Phuan PW, Veit G, Tan J, Roldan A, Finkbeiner WE, Lukacs GL, Verkman AS. Phuan PW, et al. Mol Pharmacol. 2014 Jul;86(1):42-51. doi: 10.1124/mol.114.092478. Epub 2014 Apr 15. Mol Pharmacol. 2014. PMID: 24737137 Free PMC article.

3

Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action.

Phuan PW, Veit G, Tan JA, Finkbeiner WE, Lukacs GL, Verkman AS. Phuan PW, et al. Mol Pharmacol. 2015 Oct;88(4):791-9. doi: 10.1124/mol.115.099689. Epub 2015 Aug 5. Mol Pharmacol. 2015. PMID: 26245207 Free PMC article.

4

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product.

Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS. Haggie PM, et al. Among authors: phuan pw. J Biol Chem. 2017 Jan 20;292(3):771-785. doi: 10.1074/jbc.M116.764720. Epub 2016 Nov 28. J Biol Chem. 2017. PMID: 27895116 Free PMC article.

5

ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter.

Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS. Phuan PW, et al. SLAS Discov. 2018 Sep;23(8):823-831. doi: 10.1177/2472555218763310. Epub 2018 Mar 13. SLAS Discov. 2018. PMID: 29533733 Free PMC article.

6

Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis.

Phuan PW, Yang B, Knapp JM, Wood AB, Lukacs GL, Kurth MJ, Verkman AS. Phuan PW, et al. Mol Pharmacol. 2011 Oct;80(4):683-93. doi: 10.1124/mol.111.073056. Epub 2011 Jul 5. Mol Pharmacol. 2011. PMID: 21730204 Free PMC article.

7

Fluorinated ΔF508-CFTR correctors and potentiators for PET imaging.

Davison HR, Solano DM, Phuan PW, Verkman AS, Kurth MJ. Davison HR, et al. Among authors: phuan pw. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1602-5. doi: 10.1016/j.bmcl.2011.12.128. Epub 2012 Jan 3. Bioorg Med Chem Lett. 2012. PMID: 22281185 Free PMC article.

8

Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis.

Donald MB, Rodriguez KX, Shay H, Phuan PW, Verkman AS, Kurth MJ. Donald MB, et al. Among authors: phuan pw. Bioorg Med Chem. 2012 Sep 1;20(17):5247-53. doi: 10.1016/j.bmc.2012.06.046. Epub 2012 Jul 6. Bioorg Med Chem. 2012. PMID: 22841006 Free PMC article.

9

Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis.

Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS. Haggie PM, et al. Among authors: phuan pw. FASEB J. 2016 Jun;30(6):2187-97. doi: 10.1096/fj.201600223R. Epub 2016 Mar 1. FASEB J. 2016. PMID: 26932931 Free PMC article.

10

Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases.

Lee S, Phuan PW, Felix CM, Tan JA, Levin MH, Verkman AS. Lee S, et al. Among authors: phuan pw. J Med Chem. 2017 Feb 9;60(3):1210-1218. doi: 10.1021/acs.jmedchem.6b01792. Epub 2017 Jan 31. J Med Chem. 2017. PMID: 28099811 Free PMC article.

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